Daniel Scharfenberg, Elke Kalbe, Monika Balzer-Geldsetzer, Daniela Berg, Rüdiger Hilker-Roggendorf, Jan Kassubek, Inga Liepelt-Scarfone, Brit Mollenhauer, Kathrin Reetz, Oliver Riedel, Sandra Roeske, Jörg B Schulz, Alexander Storch, Claudia Trenkwalder, Karsten Witt, Hans-Ulrich Wittchen, Richard Dodel, Anja Ophey
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引用次数: 0
摘要
前言在神经心理诊断中，认知测试的领域分配通常缺乏经验依据。因此，我们旨在评估帕金森病（PD）患者认知的维度结构，并从概念上复制认知健康者（CHIs）的研究结果：我们对DEMPARK/LANDSCAPE研究中的698名帕金森病患者的认知测试得分进行了探索性图形分析（EGA）的维度分析。在重新执行 EGA 之前，根据独特变量分析（UVA）减少了冗余。CHI数据（N = 60,398）作为概念复制基础：结果：EGA 确定了五个维度。在剔除了 UVA 识别出的冗余后，EGA 识别出了认知测试分数的单维度结构。讨论：讨论：研究结果表明，有必要重新评估认知测试的组成，以减少冗余，提高认知诊断的有效性。认知可能更适合描述为相互关联的认知功能网络，而不是潜在认知领域的因子结构：该结果表明，认知应被视为由相互关联的功能组成的复杂 "网络"。
A network perspective on cognition in individuals with Parkinson's disease.
Introduction: In neuropsychological diagnostics, the assignment of cognitive tests to domains is usually not empirically based. Hence, we aimed to assess the dimensionality structure of cognition in individuals with Parkinson's disease (PD) and conceptually replicate the findings in cognitively healthy individuals (CHIs).
Methods: We performed Exploratory Graph Analysis (EGA) for dimensionality analysis of cognitive test scores in N = 698 individuals with PD from the DEMPARK/LANDSCAPE study. Redundancy was reduced based on Unique Variable Analysis (UVA) before re-performing EGA. CHI data (N = 60,398) served as a conceptual replication base.
Results: EGA identified five dimensions. After removing redundancy identified by UVA, EGA identified a unidimensional structure of cognitive test scores. The findings were conceptually replicated in CHIs.
Discussion: The findings imply the need to re-evaluate the composition of cognitive test batteries to reduce redundancy and improve the validity of cognitive diagnostics. Cognition may be better described as a network of interrelated cognitive functions rather than a factorial structure of latent cognitive domains.
Highlights: Cognitive test scores of the same paradigm were strongly associated with each other.This finding indicates redundancy in the cognitive test battery.After removing redundancy, scores were best represented by unidimensional structures.The findings in Parkinson's disease were conceptually replicated in healthy controls.The results suggest that cognition should be viewed as a complex "network" of interrelated functions.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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