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IF 3.1 3区医学 Q2 ONCOLOGY Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-22 DOI:10.1016/j.pdpdt.2025.104531

Po-Chin Kuo , Sheng-Min Hsu , Yi-Hsun Huang , Chun-Hsiang Chang , Yi-Sheng Chang , Jia-Horung Hung , Chun-Chieh Lai , Yu-Kuei Lee

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引用次数: 0

摘要

目的：在多形性脉络膜血管病（PCV）患者中，比较玻璃体内雷尼珠单抗（Lucentis）（IVR）加光动力疗法（PDT）与玻璃体内阿弗利百普（Eylea）（IVA）单药治疗的脉络膜血管密度：设计：一项前瞻性队列观察研究：干预：IVR 加 PDT 或 IVA 单药治疗：经过倾向分数（PS）匹配后，比较最终治疗后 1 个月的研究结果。主要结果是光学相干断层血管造影（OCTA）确认的绒毛膜血管密度。次要结果包括光学相干断层扫描（OCT）评估的最佳矫正视力（BCVA）、视网膜出血、黄斑中心厚度（CMT）和眼底脉络膜厚度（SFCT）：最初纳入了23名接受IVR加PDT治疗的患者和75名接受IVA单药治疗的患者。经过PS匹配后，对19名接受IVR加PDT治疗的患者的19只眼睛和38名接受IVA单药治疗的患者的38只眼睛进行了分析。结果显示，IVR 加 PDT 组的绒毛膜血管密度明显低于 IVA 单药治疗组（41.9% 对 52.2%，P= 0.009）。两组患者的 BCVA、视网膜出血、CMT 和 SFCT 的发生率和严重程度相似：结论：与接受 IVA 单药治疗的 PCV 患者相比，接受 IVR 加 PDT 治疗的 PCV 患者绒毛膜血管密度明显降低。

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Impact of photodynamic therapy combined with Anti-VEGF vs. Anti-VEGF monotherapy on choriocapillaris vessel density in polypoidal choroidal vasculopathy

Purpose

To compare the choriocapillaris vessel density between intravitreal ranibizumab (Lucentis) (IVR) plus photodynamic therapy (PDT) and intravitreal aflibercept (Eylea) (IVA) monotherapy in patients experiencing polypoidal choroidal vasculopathy (PCV).

Design

An observational, retrospective cohort study.

Subjects

Adults with treatment-naïve PCV.

Intervention

IVR plus PDT or IVA monotherapy.

Main outcome measures

After propensity-score (PS) matching, study outcomes were compared at 1 month after the final treatment. The primary outcome was a choriocapillaris vessel density, recognized by optical coherence tomography angiography (OCTA). The secondary outcomes included best corrected visual acuity (BCVA), presence of retinal hemorrhage, central macular thickness (CMT) and subfoveal choroidal thickness (SFCT), assessed by optical coherence tomography (OCT).

Results

Initially, 23 patients receiving IVR plus PDT, and 75 patients receiving IVA monotherapy were included. After PS-matching, 19 eyes of 19 patients receiving IVR plus PDT and 38 eyes of 38 patients receiving IVA monotherapy were analyzed. A significantly lower choriocapillaris vessel density in the IVR plus PDT group than the IVA monotherapy group (41.9 % vs. 52.2 %, p = 0.009) was demonstrated. The similarity of the BCVA, occurrence and severity of retinal hemorrhage, CMT, and SFCT between two treatment groups was exhibited.

Conclusions

The choriocapillaris vessel density was significantly reduced in PCV patients treated with IVR plus PDT compared to those receiving IVA monotherapy.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.