PAR6-aPKC-LGL结构揭示了LGL如何拮抗aPKC

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nature Structural & Molecular Biology Pub Date : 2025-02-27 DOI:10.1038/s41594-025-01506-8

Daniel St Johnston

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引用次数: 0

摘要

上皮细胞的顶基极性取决于顶端aPKC和外侧LGL蛋白之间的相互拮抗作用。到目前为止，还不清楚LGL是如何同时作为aPKC的底物和抑制剂的。现在，一种停滞不前的PAR6-aPKC-LGL复合物的低温电子显微镜（cryo-EM）结构解决了这个难题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC

The apical–basal polarity of epithelial cells depends on mutual antagonism between the apical aPKC and lateral LGL proteins. Until now, it has been unclear how LGL can be both a substrate and inhibitor of aPKC. Now, a cryo-electron microscopy (cryo-EM) structure of a stalled PAR6–aPKC–LGL complex addresses this conundrum.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.