Vanessa Buffa, Carlo Walz, Dr. Christian Meyners, Dr. Min Zheng, Wisely Oki Sugiarto, Maximilian Repity, Hanaa Achaq, Christian Brudy, Moritz Spiske, Matijas Cica, Prof. Dr. Felix Hausch
{"title":"在宏观周期中通过链接派生提高构象可塑性和结合亲和力。","authors":"Vanessa Buffa, Carlo Walz, Dr. Christian Meyners, Dr. Min Zheng, Wisely Oki Sugiarto, Maximilian Repity, Hanaa Achaq, Christian Brudy, Moritz Spiske, Matijas Cica, Prof. Dr. Felix Hausch","doi":"10.1002/ange.202581061","DOIUrl":null,"url":null,"abstract":"<p>Macrocycles like the ones depicted in the rod-and-ball representation shown in the picture can enable powerful drugs but their exploration has been difficult. The build--pair--couple strategy reported by Felix Hausch et al. in their Research Article (e202418512) allows the rapid assembly of diversely decorated macrocycles, especially in the linker part (highlighted in orange).\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"137 10","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202581061","citationCount":"0","resultStr":"{\"title\":\"Frontispiz: Konformationsplastizität und Steigerung der Bindungsaffinität durch Linker-Derivatisierung in Makrozyklen\",\"authors\":\"Vanessa Buffa, Carlo Walz, Dr. Christian Meyners, Dr. Min Zheng, Wisely Oki Sugiarto, Maximilian Repity, Hanaa Achaq, Christian Brudy, Moritz Spiske, Matijas Cica, Prof. Dr. Felix Hausch\",\"doi\":\"10.1002/ange.202581061\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Macrocycles like the ones depicted in the rod-and-ball representation shown in the picture can enable powerful drugs but their exploration has been difficult. The build--pair--couple strategy reported by Felix Hausch et al. in their Research Article (e202418512) allows the rapid assembly of diversely decorated macrocycles, especially in the linker part (highlighted in orange).\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure>\\n </p>\",\"PeriodicalId\":7803,\"journal\":{\"name\":\"Angewandte Chemie\",\"volume\":\"137 10\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202581061\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Angewandte Chemie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ange.202581061\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angewandte Chemie","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ange.202581061","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Frontispiz: Konformationsplastizität und Steigerung der Bindungsaffinität durch Linker-Derivatisierung in Makrozyklen
Macrocycles like the ones depicted in the rod-and-ball representation shown in the picture can enable powerful drugs but their exploration has been difficult. The build--pair--couple strategy reported by Felix Hausch et al. in their Research Article (e202418512) allows the rapid assembly of diversely decorated macrocycles, especially in the linker part (highlighted in orange).
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
