Jungmoo Huh, Eun Jin Park, Jae Hyun Lee, Chan-Woong Park, Tae-Jin Yang, Won Keun Oh, Young-Won Chin
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New abietane-type diterpenoids from roots of Euonymus hamiltonianus and their cytotoxicity in human cancer cell.
Two new abietane-type diterpenoids, 6β-(3-furoyloxy)ferruginol (1) and 6-chloro-6,7-dehydroferruginol (2), were isolated from the roots of Euonymus hamiltonianus along with five known diterpenoids (3-7). Their structures were characterized using various spectroscopic analysis including HRMS, 1D and 2D NMR, and ECD analysis. All isolated compounds (1-7) were evaluated for their cytotoxic activity against human colon cancer cell line, HCT116, and it was found to exhibit moderate cytotoxic activity with IC50 values ranging from 4.5 to 22.9 μM. Among the isolated compounds, montbretol (4) displayed the most cytotoxic activity (IC50 = 4.50 ± 0.29 μM) against HCT116 human colon cancer cells than the other isolated compounds.
期刊介绍：
The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers:
-chemistry of natural products
-biochemistry of medicinal plants
-pharmacology of natural products and herbs, including Kampo formulas and traditional herbs
-botanical anatomy
-cultivation of medicinal plants.
The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.
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