Recent Developments in C−H Functionalization and Annulation of 2-Aryl-Quinazolinones and 3-Aryl-Quinazolinones via Site Selective Transformations

Quinazolinone is a crucial scaffold in numerous natural compounds, as well as in biologically active and functional materials. Consequently, various synthetic methods have been developed to transform quinazolinone and its derivatives. Site selective C−H bond functionalization and annulation of the 2-aryl-quinazolinones and 3-aryl-quinazolinones skeleton through transition-metal catalysis offer an efficient approach to obtain diverse substituted nitrogen-containing heterocyclic frameworks. This review summarizes recent reports on transition-metal catalyzed site selective transformations of 2-aryl-quinazolinone and 3-aryl-quinazolinones through C−H functionalization and annulation reactions.