Synthesis, Antioxidant and antimicrobial activities of some imidazo[4,5-d]pyridine derivatives

This work covers the multifunctional capabilities of imidazo[4,5-d]pyridine series, previously designed, synthesized and tested for its corrosion, inhibitory activity, as well as its inhibition of tyrosyl-tRNA synthetase activity. The study extends to the evaluation of their antimicrobial and antioxidant capacities. In particular, compound 1c shows significant antioxidant effects, highlighting potential applications against oxidative stress. Antibacterial studies reveal its efficacy, particularly against Staphylococcus aureus, suggesting targeted antibacterial applications. Furthermore, antifungal evaluations revealed that compound 1c (with 2-phenylnitro group in position 2) can also inhibit the mycelial growth of Fusarium oxysporum, thus broadening its spectrum of bioactivity. These results not only underline the diverse pharmacological potential of imidazopyridine derivatives but also provide crucial information for future drug design and development.