乳腺癌患者化疗后脑电图微态动力学和认知的变化

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES Brain and Behavior Pub Date : 2025-03-04 DOI:10.1002/brb3.70335

S. Damji, S. Sattari, K. Zadravec, K. L. Campbell, J. Brunet, N. Virji-Babul

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引用次数: 0

摘要

目的乳腺癌化疗后认知功能改变的报道较多；然而，大规模神经网络的脑动力学变化尚不清楚。利用“乳腺癌女性有氧运动和认知功能”（ACTIVATE）试验的数据，我们进行了探索性分析，比较了乳腺癌女性化疗前后的自我报告和客观认知测量，并将微状态分析应用于静息状态（RS）脑电图（EEG）数据。方法对8例30 ~ 52岁女性患者（平均年龄44.8岁，SD = 7.3岁）的资料进行分析。使用PROMIS（患者报告结果测量信息系统）和Trail Making Test （TMT）评估认知功能。同时采集5分钟RS闭眼脑电图数据。提取7个脑电微状态，计算平均微状态持续时间和发生次数。结果化疗后，两组患者PROMIS评分显著降低（p = 0.003, d = 1.601）， TMT评分差异无统计学意义。总体而言，微状态持续时间明显更长(p <；0.001, d = 2.837)，化疗后分布不均匀。化疗后微状态D（涉及注意/执行功能）的平均持续时间显著增加（p = 0.007, D = 1.339）。比较表现出大效应量的行为和微观状态测量，在化疗前后均未观察到显著相关性。结论我们观察到化疗后RS脑自我报告的认知障碍和功能动力学紊乱。这项探索性研究使用队列内设计提供了新的证据，表明化疗的认知效应与大范围脑动力学的变化有关。临床试验注册。gov标识符：NCT03277898

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Changes in EEG Microstate Dynamics and Cognition Post-Chemotherapy in People With Breast Cancer

Objective

Chemotherapy-related cognitive changes following breast cancer are commonly reported; however, changes in brain dynamics of large-scale neural networks remain unclear. Using data from the Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial, we conducted exploratory analyses to compare self-reported and objective measures of cognition and applied microstate analysis to resting state (RS) electroencephalography (EEG) data of women with breast cancer before and following chemotherapy treatment.

Methods

Data from eight female participants between the ages of 30 and 52 (mean age = 44.8 years, SD = 7.3 years) were analyzed. Cognitive function was assessed using the PROMIS (Patient-Reported Outcomes Measurement Information System) and the Trail Making Test (TMT). Five minutes of RS eyes-closed EEG data were also collected. Seven EEG microstates were extracted, and mean microstate duration and occurrence were computed.

Results

Following chemotherapy, there was a significant decrease in the PROMIS score (p = 0.003, d = 1.601), but no significant difference in the TMT score. Overall, microstate durations were significantly longer (p < 0.001, d = 2.837) and less evenly distributed following chemotherapy. The mean duration of microstate D (involved in attention/executive functions) significantly increased following chemotherapy (p = 0.007, d = 1.339). Comparing behavioral and microstate measures that exhibited a large effect size, no significant correlations were observed either before or after chemotherapy.

Conclusions

We observed self-reported cognitive impairment and disturbed functional dynamics in the RS brain following chemotherapy. This exploratory study provides new evidence using a within-cohort design showing that changes occur in large scale brain dynamics related to the cognitive effects of chemotherapy.

Trial Registration

ClinicalTrials.gov identifier: NCT03277898

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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