{"title":"新的机制强调载脂蛋白E与tau发病机制的复杂关系。","authors":"Paramita Chakrabarty, Conner Angelle","doi":"10.1016/j.neuron.2025.01.025","DOIUrl":null,"url":null,"abstract":"<p><p>A rare variant of Apolipoprotein E3 with neuroprotective properties has been identified in autosomal-dominant Alzheimer's disease. In this issue of Neuron, Chen et al.<sup>1</sup> show that direct interaction between this variant and tau blocks tau pathogenesis in rodent models.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":"113 5","pages":"646-648"},"PeriodicalIF":15.0000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New mechanisms highlight the complex relationship of Apolipoprotein E and tau pathogenesis.\",\"authors\":\"Paramita Chakrabarty, Conner Angelle\",\"doi\":\"10.1016/j.neuron.2025.01.025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A rare variant of Apolipoprotein E3 with neuroprotective properties has been identified in autosomal-dominant Alzheimer's disease. In this issue of Neuron, Chen et al.<sup>1</sup> show that direct interaction between this variant and tau blocks tau pathogenesis in rodent models.</p>\",\"PeriodicalId\":19313,\"journal\":{\"name\":\"Neuron\",\"volume\":\"113 5\",\"pages\":\"646-648\"},\"PeriodicalIF\":15.0000,\"publicationDate\":\"2025-03-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuron\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.neuron.2025.01.025\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuron","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neuron.2025.01.025","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
New mechanisms highlight the complex relationship of Apolipoprotein E and tau pathogenesis.
A rare variant of Apolipoprotein E3 with neuroprotective properties has been identified in autosomal-dominant Alzheimer's disease. In this issue of Neuron, Chen et al.1 show that direct interaction between this variant and tau blocks tau pathogenesis in rodent models.
期刊介绍：
Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.
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