IF 5.4 2区 医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2025-02-24 DOI:10.1021/acsbiomaterials.4c0222210.1021/acsbiomaterials.4c02222
Tim Y. Li, Sophia Salingaros, Hector F. Salazar, Riley D. Mayne, Jini Jeon, Carlos Urrea de la Puerta, Matthew W. Liao, Samuel J. Medina, Xue Dong, Lawrence J. Bonassar and Jason A. Spector*, 
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摘要

背景:由于与乳房假体相关性大细胞淋巴瘤(Breast Implant-Associated Anaplastic Large Cell Lymphoma)有关,全球范围内有几种纹理的乳房假体型号被自愿召回和禁用,这限制了纹理表面的主要优点--定位稳定性。我们设计了一种位置稳定光滑假体 (PSSI),假体表面有毫米级的圆柱形孔,用于胶囊的生长和设备的稳定。目标:评估 PSSI 设计在体内的长期位置稳定性,并确定囊形成的特征。方法:使用聚二甲基硅氧烷制造微型乳房植入物。PSSI 设计有不同的孔宽、深度和数量。对比组包括光滑植入物和纹理植入物。每组 6 个已消毒的植入物被植入 Sprague-Dawley 大鼠的双侧背皮下。每两周用 MicroCT 测量一次种植体的旋转。3 个月后取出植入物-囊单元进行组织学分析。结果:所有 PSSI 组的累积位置旋转均明显低于光滑种植体(p < 0.05),稳定性与纹理种植体相当。取出后,显微 CT 和大体检查显示 PSSI 井内有明显的囊袋增生。异物反应的组织学评估显示,与纹理对照组相比,PSSI 胶囊中的促炎 M1 巨噬细胞明显减少。此外,与光滑植入物相比,PSSI 组和纹理组的肌成纤维细胞表达明显较低,而肌成纤维细胞表达与囊挛缩有关。结论:与纹理假体相比,这种新型光滑表面乳房假体设计提供了同等的位置稳定性,并减少了促炎性 M1 巨噬细胞的表达。这些结果表明,在诱导体位稳定性方面,光面假体是一种有前途的、更安全的纹理假体替代品。
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Designing Positionally Stable Smooth Breast Implants

Background: The voluntary recall and ban of several textured breast implant models worldwide, secondary to their association with Breast Implant-Associated Anaplastic Large Cell Lymphoma, has limited the key benefit of a textured surface─positional stability. We have engineered a Positionally Stable Smooth Implant (PSSI) containing millimeter-scaled cylindrical wells on the implant surface for capsule ingrowth and device stabilization. Objectives: To evaluate the long-term positional stability of PSSI designs in vivo and characterize capsule formation. Methods: Miniature breast implants were manufactured using poly(dimethylsiloxane). PSSI were designed with various dimensions of well width, depth, and number. Comparison groups consisted of smooth and textured implants. Six sterilized implants per group were implanted subcutaneously into the bilateral dorsa of Sprague–Dawley rats. Implant rotation was measured with MicroCT every 2 weeks. Implant-capsule units were explanted at 3 months for histological analysis. Results: All PSSI groups exhibited significantly less cumulative positional rotation than smooth implants (p < 0.05), with stability comparable to that of textured implants. Upon explantation, microCT and gross examination revealed notable capsule ingrowth within the PSSI wells. Histological evaluation of foreign body response showed significantly fewer pro-inflammatory M1 macrophages in the PSSI capsules compared to the textured control. Additionally, myofibroblast expression, which is implicated in capsular contracture, was significantly lower in both the PSSI and textured groups compared to smooth implants. Conclusions: This novel smooth-surface breast implant design provided equivalent positional stability and reduced pro-inflammatory M1 macrophage expression compared to textured implants. These results suggest a promising, safer alternative to textured implants for inducing positional stability.

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来源期刊
ACS Biomaterials Science & Engineering
ACS Biomaterials Science & Engineering Materials Science-Biomaterials
CiteScore
10.30
自引率
3.40%
发文量
413
期刊介绍: ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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