多模态成像用于评估和量化假性黄斑萎缩的萎缩进展。

IF 3.1 3区 医学 Q2 ONCOLOGY Photodiagnosis and Photodynamic Therapy Pub Date : 2025-03-05 DOI:10.1016/j.pdpdt.2025.104550
Rukiye Aydin, Merve Ozbek, Ozgur Artunay
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Multimodal imaging for evaluation and quantification of atrophy progression in extensive macular atrophy with pseudodrusen

Aim

To present the atrophy progression rate with fundus autofluorescence (FAF) and optical coherence tomography (OCT) findings in patients with extensive macular atrophy with a pseudodrusen-like appearance.

Methods

Eight patients who were followed up with the diagnosis of diffuse macular atrophy accompanied by pseudodrusen were included. Medical records, FAF, and OCT images at consecutive follow-ups were reviewed. Measurement of the atrophic area was performed on FAF images using the Heidelberg RegionFinder software at baseline and each annual visit until the last available follow-up.

Results

The mean age was 56.75 ± 5.92 years (range, 45–65 years). Nyctalopia was observed in all patients. Macular atrophy of various sizes with a larger vertical diameter was present. Diffuse pseudodrusen-like deposits extending to the mid-peripheral retina were identified. The mean follow-up period was 38.33 ± 14.60 months (range, 26–60 months). The mean area of atrophy at baseline was 13.05 ± 7.93 mm2 and reached 15.31 ± 7.93 mm2 at the first-year follow-up (p < 0.001). At the end of the follow-up period, the mean area of atrophy was 17.32 ± 7.90 mm2 (p = 0.001). The yearly rate of atrophy expansion was 2.13 mm2/year. The mean subfoveal choroidal thickness at baseline decreased markedly during the follow-up period (p = 0.000).

Conclusions

The progression rate of macular atrophy in these patients is faster than the geographic atrophy associated with age-related macular degeneration. In this era of therapeutic options, it has become more important to assess atrophy progression. Distinguishing different macular atrophy forms may be crucial for selecting suitable candidates for future interventional treatments.
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来源期刊
CiteScore
5.80
自引率
24.20%
发文量
509
审稿时长
50 days
期刊介绍: Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.
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