早老素平衡自噬和细胞外囊泡分泌

IF 10.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nature Structural & Molecular Biology Pub Date : 2025-03-11 DOI:10.1038/s41594-025-01513-9
Melina Casadio
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引用次数: 0

摘要

Presenilin 1 和 2(统称 PSENs)是与家族性阿尔茨海默病有关的跨膜蛋白。PSENs是γ-分泌酶的一部分,γ-分泌酶是一种蛋白酶复合物,有助于从淀粉样蛋白前体(APP)生成淀粉样-β蛋白。自噬是细胞回收细胞器和大分子的过程。研究人员观察到,缺乏 PSENs 的小鼠胚胎成纤维细胞分泌的小细胞外囊泡(sEVs)数量减少。缺乏PSEN的细胞显示出多泡内质体(MVE)蛋白CD63的定位模式受损,免疫染色总信号减少,CD63与自噬囊泡标记物的共定位增加。自噬标记物的水平和超微结构分析表明,在没有 PSENs 的情况下,自噬可能会过度诱导;用巴磷霉素 A1 阻止溶酶体功能和自噬有助于增加 CD63 的数量。这些数据共同表明,缺乏 PSEN 的细胞将 MVEs 靶向溶酶体进行降解,这可能会降低 MVEs 与质膜融合和分泌 sEVs 的可用性。
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Presenilins balancing autophagy and extracellular vesicle secretion
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来源期刊
Nature Structural & Molecular Biology
Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS
CiteScore
22.00
自引率
1.80%
发文量
160
审稿时长
3-8 weeks
期刊介绍: Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.
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