Maoshuai Fu , Minrui Liao , Yingmei Qin , Lixuan He , Zhihong Zheng , Yongzhen Zhao , Qingyun Liu , Yueling Zhang , Xianliang Zhao
{"title":"血青素来源的抗菌肽PvL1通过调节凡纳滨对虾肝胰腺微生物群防御AHPND感染","authors":"Maoshuai Fu , Minrui Liao , Yingmei Qin , Lixuan He , Zhihong Zheng , Yongzhen Zhao , Qingyun Liu , Yueling Zhang , Xianliang Zhao","doi":"10.1016/j.fsi.2025.110267","DOIUrl":null,"url":null,"abstract":"<div><div>Antimicrobial peptides (AMPs) play a crucial role in maintaining the balance of host microbiota, serving as the first line of defense against pathogenic microorganisms. However, the potential mechanisms by which AMPs modulate microbial homeostasis are not fully understood. In this study, we showed that <em>Vibrio parahaemolyticus</em> (VP<sub>AHPND</sub>) infection could suppress the expression of hemocyanin and promote its degradation. <em>Pv</em>L1, a hemocyanin-derived AMP, exhibited high antibacterial activity against AHPND infection. Then, it was observed that <em>Pv</em>L1 could restore the dysbiosis in the hepatopancreas microbiota of AHPND shrimps. In addition, <em>Pv</em>L1 could increase the survival of shrimp against VP<sub>AHPND</sub> infection by modulating the predominance of bacteria in the hepatopancreas microbiota. Taken together, these findings highlight the crucial role of hemocyanin-derived peptides in maintaining homeostasis in the hepatopancreas microbiota in response to AHPND disease.</div></div>","PeriodicalId":12127,"journal":{"name":"Fish & shellfish immunology","volume":"161 ","pages":"Article 110267"},"PeriodicalIF":3.9000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hemocyanin-derived antimicrobial peptide PvL1 defense against AHPND infection by regulating the hepatopancreatic microbiota of Penaeus vannamei\",\"authors\":\"Maoshuai Fu , Minrui Liao , Yingmei Qin , Lixuan He , Zhihong Zheng , Yongzhen Zhao , Qingyun Liu , Yueling Zhang , Xianliang Zhao\",\"doi\":\"10.1016/j.fsi.2025.110267\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Antimicrobial peptides (AMPs) play a crucial role in maintaining the balance of host microbiota, serving as the first line of defense against pathogenic microorganisms. However, the potential mechanisms by which AMPs modulate microbial homeostasis are not fully understood. In this study, we showed that <em>Vibrio parahaemolyticus</em> (VP<sub>AHPND</sub>) infection could suppress the expression of hemocyanin and promote its degradation. <em>Pv</em>L1, a hemocyanin-derived AMP, exhibited high antibacterial activity against AHPND infection. Then, it was observed that <em>Pv</em>L1 could restore the dysbiosis in the hepatopancreas microbiota of AHPND shrimps. In addition, <em>Pv</em>L1 could increase the survival of shrimp against VP<sub>AHPND</sub> infection by modulating the predominance of bacteria in the hepatopancreas microbiota. Taken together, these findings highlight the crucial role of hemocyanin-derived peptides in maintaining homeostasis in the hepatopancreas microbiota in response to AHPND disease.</div></div>\",\"PeriodicalId\":12127,\"journal\":{\"name\":\"Fish & shellfish immunology\",\"volume\":\"161 \",\"pages\":\"Article 110267\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fish & shellfish immunology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1050464825001561\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"FISHERIES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fish & shellfish immunology","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1050464825001561","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/8 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"FISHERIES","Score":null,"Total":0}
Hemocyanin-derived antimicrobial peptide PvL1 defense against AHPND infection by regulating the hepatopancreatic microbiota of Penaeus vannamei
Antimicrobial peptides (AMPs) play a crucial role in maintaining the balance of host microbiota, serving as the first line of defense against pathogenic microorganisms. However, the potential mechanisms by which AMPs modulate microbial homeostasis are not fully understood. In this study, we showed that Vibrio parahaemolyticus (VPAHPND) infection could suppress the expression of hemocyanin and promote its degradation. PvL1, a hemocyanin-derived AMP, exhibited high antibacterial activity against AHPND infection. Then, it was observed that PvL1 could restore the dysbiosis in the hepatopancreas microbiota of AHPND shrimps. In addition, PvL1 could increase the survival of shrimp against VPAHPND infection by modulating the predominance of bacteria in the hepatopancreas microbiota. Taken together, these findings highlight the crucial role of hemocyanin-derived peptides in maintaining homeostasis in the hepatopancreas microbiota in response to AHPND disease.
期刊介绍：
Fish and Shellfish Immunology rapidly publishes high-quality, peer-refereed contributions in the expanding fields of fish and shellfish immunology. It presents studies on the basic mechanisms of both the specific and non-specific defense systems, the cells, tissues, and humoral factors involved, their dependence on environmental and intrinsic factors, response to pathogens, response to vaccination, and applied studies on the development of specific vaccines for use in the aquaculture industry.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
