IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Diagnostics Pub Date : 2025-03-05 DOI:10.3390/diagnostics15050621
Mücahid Yılmaz, Çetin Mirzaoğlu
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摘要

背景:心率湍流(HRT)是一种无创技术,可用于评估自律神经系统(ANS)功能和心律失常。本研究的目的是调查 COVID-19 是否会导致恢复后的心率湍流长期减弱。研究方法这项回顾性队列研究包括 253 名确诊感染过 COVID-19 的患者(称为 COVID-19 康复者组)和 315 名无病毒感染史的健康参与者。根据胸部 CT 的严重程度评分,COVID-19 康复者组被分为三个亚组。心率变异分析是通过 24 小时心电图-霍尔特记录获得的。结果研究显示,与对照组相比,COVID-19康复组的心率变异起始值升高,而心率变异斜率值则显著下降。相关性分析表明,胸部 CT 严重程度评分与 HRT 开始值呈正相关,而胸部 CT 严重程度评分与 HRT 斜率值呈负相关。回归分析表明,从严重 COVID-19 中恢复、胸部 CT 严重程度评分、高血压 (HT) 和吸烟是异常 HRT 开始和异常 HRT 斜坡存在的独立预测因素。结论是从严重 COVID-19 中康复的人预计会出现永久性的 HRT 变钝,这被认为是室性心律失常风险增加和自主神经系统 (ANS) 功能受损的一个重要指标。严重 COVID-19 患者康复后应通过 24 小时心电图-霍尔特仔细评估心率变异。
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Retrospective Cohort Study: Severe COVID-19 Leads to Permanent Blunted Heart Rate Turbulence.

Background: Heart rate turbulence (HRT) is a non-invasive technique that can be used to evaluate autonomic nervous system (ANS) function and cardiac arrhythmia. The objective of this study is to investigate whether COVID-19 can lead to long-term blunted HRT following recovery. Methods: This retrospective cohort study included 253 individuals with a confirmed history of COVID-19, referred to as the recovered COVID-19 group, along with 315 healthy participants who had no history of the virus. The recovered COVID-19 group was categorized into three subgroups based on their chest CT severity scores. The HRT analyses were obtained from a 24-h electrocardiography-Holter recording. Results: This study revealed that the HRT onset value was elevated in the recovered COVID-19 group, while the HRT slope value showed a significant decrease when compared to the control group. Correlation analyses indicated a positive relationship between the chest CT severity score and HRT onset, whereas a negative correlation was observed between the chest CT severity score and HRT slope. Regression analyses identified recovery from severe COVID-19, chest CT severity score, hypertension (HT), and smoking as independent predictors of both abnormal HRT onset and the existence of an abnormal HRT slope. Conclusions: Individuals who have recovered from severe COVID-19 are expected to encounter a permanent blunting of HRT, which is regarded as a significant indicator of an increased risk of ventricular arrhythmias and impaired autonomic nervous system (ANS) function. Recovered severe COVID-19 individuals should be carefully evaluated for HRT with 24-h ECG-Holter.

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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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