Dr. Lingfei Hu, Wenyao Ding, Wei Liu, Limeng Wang, Dr. Xiangying Lv, Prof. Gang Lu
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Origin of Regioselectivity Switch in Pyridinium Functionalizations with Phosphinoyl and Carbamoyl Radicals
The origins of regioselectivity switch in pyridinium phosphinoylation and carbamoylation were computationally investigated using energy decomposition analysis. The results reveal that the preference for regioselectivity arises from distinct intermolecular interactions between phosphinoyl/carbamoyl radicals and pyridinium derivatives. The ortho-methoxy group on pyridinium remodulates different types of intermolecular interactions, exhibiting an opposite trend in its influence on para versus ortho selectivity.
期刊介绍：
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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