{"title":"经颅磁刺激与阿尔茨海默病研究热点与趋势的文献计量学分析。","authors":"Dingwen Xu, Yang Feng, Zhihua Lu, Ruijia Ma, Weicai Zhang, Zhen Mou, Lingling Zhang, Xiufeng Tang, Zhenxiong Zhao, Zhencang Zheng","doi":"10.3389/fnagi.2025.1544702","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Research regarding Transcranial Magnetic Stimulation (TMS) and Alzheimer's disease (AD) has been increasing; however, no bibliometric analysis has yet been conducted in this domain. This study employs bibliometric methods to identify research trends and hotspots concerning AD and TMS.</p><p><strong>Methods: </strong>We conducted a search in the Web of Science Core Database for articles related to AD and TMS from January 1, 2014, to October 22, 2024. After stringent selection, we performed bibliometric analysis using Excel, VOSviewer, CiteSpace and CoreMine.</p><p><strong>Results: </strong>The number of articles pertaining to AD and TMS has increased annually, with a notable surge post-2020. The three leading countries in publication volume are China, the United States, and Italy. The top institutions contributing to this field include Harvard Medical School, the University of Toronto, and the University of Brescia. The author with the highest publication output is Giacomo Koch. The journal with the most publications is the Journal of Alzheimer's disease. The 10 most frequently occurring keywords are Alzheimer's disease, Transcranial Magnetic Stimulation, mild cognitive impairment, dementia, memory, double-blind, repetitive transcranial magnetic stimulation, noninvasive brain stimulation, cognitive impairment, and plasticity. Text mining has revealed that the anatomical structure \"brain\" and the gene \"Amyloid Precursor Protein (APP)\" are significantly related to both AD and TMS, suggesting that TMS may offer a therapeutic avenue for AD by modulating the activity of APP.</p><p><strong>Conclusion: </strong>Our article employs bibliometric methods to unveil trends in research related to AD and TMS, including collaborations among countries, regions, and authors, as well as key research hotspots. We provide objective data that serves as a reference for scientific research and clinical work concerning AD and TMS.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1544702"},"PeriodicalIF":4.5000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903466/pdf/","citationCount":"0","resultStr":"{\"title\":\"A bibliometric analysis of research hotspots and trends in transcranial magnetic stimulation and Alzheimer's disease.\",\"authors\":\"Dingwen Xu, Yang Feng, Zhihua Lu, Ruijia Ma, Weicai Zhang, Zhen Mou, Lingling Zhang, Xiufeng Tang, Zhenxiong Zhao, Zhencang Zheng\",\"doi\":\"10.3389/fnagi.2025.1544702\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Research regarding Transcranial Magnetic Stimulation (TMS) and Alzheimer's disease (AD) has been increasing; however, no bibliometric analysis has yet been conducted in this domain. This study employs bibliometric methods to identify research trends and hotspots concerning AD and TMS.</p><p><strong>Methods: </strong>We conducted a search in the Web of Science Core Database for articles related to AD and TMS from January 1, 2014, to October 22, 2024. After stringent selection, we performed bibliometric analysis using Excel, VOSviewer, CiteSpace and CoreMine.</p><p><strong>Results: </strong>The number of articles pertaining to AD and TMS has increased annually, with a notable surge post-2020. The three leading countries in publication volume are China, the United States, and Italy. The top institutions contributing to this field include Harvard Medical School, the University of Toronto, and the University of Brescia. The author with the highest publication output is Giacomo Koch. The journal with the most publications is the Journal of Alzheimer's disease. The 10 most frequently occurring keywords are Alzheimer's disease, Transcranial Magnetic Stimulation, mild cognitive impairment, dementia, memory, double-blind, repetitive transcranial magnetic stimulation, noninvasive brain stimulation, cognitive impairment, and plasticity. Text mining has revealed that the anatomical structure \\\"brain\\\" and the gene \\\"Amyloid Precursor Protein (APP)\\\" are significantly related to both AD and TMS, suggesting that TMS may offer a therapeutic avenue for AD by modulating the activity of APP.</p><p><strong>Conclusion: </strong>Our article employs bibliometric methods to unveil trends in research related to AD and TMS, including collaborations among countries, regions, and authors, as well as key research hotspots. We provide objective data that serves as a reference for scientific research and clinical work concerning AD and TMS.</p>\",\"PeriodicalId\":12450,\"journal\":{\"name\":\"Frontiers in Aging Neuroscience\",\"volume\":\"17 \",\"pages\":\"1544702\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-02-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903466/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Aging Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fnagi.2025.1544702\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Aging Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnagi.2025.1544702","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：经颅磁刺激（TMS）与阿尔茨海默病（AD）的研究越来越多；然而，在这一领域尚未进行文献计量分析。本研究采用文献计量学方法识别AD与经颅磁刺激的研究趋势和热点。方法：检索Web of Science Core Database中2014年1月1日至2024年10月22日与AD和TMS相关的文章。经过严格筛选，我们使用Excel、VOSviewer、CiteSpace和CoreMine进行文献计量学分析。结果：与AD和TMS相关的文章数量逐年增加，并在2020年后出现显著增长。出版数量最多的三个国家是中国、美国和意大利。在这一领域做出贡献的顶尖机构包括哈佛医学院、多伦多大学和布雷西亚大学。发表量最高的作者是Giacomo Koch。发表论文最多的杂志是《阿尔茨海默病杂志》。出现频率最高的10个关键词是阿尔茨海默病、经颅磁刺激、轻度认知障碍、痴呆、记忆、双盲、重复经颅磁刺激、无创脑刺激、认知障碍和可塑性。文本挖掘揭示了AD和TMS的解剖结构“脑”和基因“淀粉样前体蛋白（APP）”显著相关，表明TMS可能通过调节APP的活性为AD的治疗提供了一条途径。结论：本文采用文献计量学方法揭示了AD和TMS的相关研究趋势，包括国家、地区、作者之间的合作，以及重点研究热点。为AD与经颅磁刺激相关的科学研究和临床工作提供客观数据参考。
A bibliometric analysis of research hotspots and trends in transcranial magnetic stimulation and Alzheimer's disease.
Background: Research regarding Transcranial Magnetic Stimulation (TMS) and Alzheimer's disease (AD) has been increasing; however, no bibliometric analysis has yet been conducted in this domain. This study employs bibliometric methods to identify research trends and hotspots concerning AD and TMS.
Methods: We conducted a search in the Web of Science Core Database for articles related to AD and TMS from January 1, 2014, to October 22, 2024. After stringent selection, we performed bibliometric analysis using Excel, VOSviewer, CiteSpace and CoreMine.
Results: The number of articles pertaining to AD and TMS has increased annually, with a notable surge post-2020. The three leading countries in publication volume are China, the United States, and Italy. The top institutions contributing to this field include Harvard Medical School, the University of Toronto, and the University of Brescia. The author with the highest publication output is Giacomo Koch. The journal with the most publications is the Journal of Alzheimer's disease. The 10 most frequently occurring keywords are Alzheimer's disease, Transcranial Magnetic Stimulation, mild cognitive impairment, dementia, memory, double-blind, repetitive transcranial magnetic stimulation, noninvasive brain stimulation, cognitive impairment, and plasticity. Text mining has revealed that the anatomical structure "brain" and the gene "Amyloid Precursor Protein (APP)" are significantly related to both AD and TMS, suggesting that TMS may offer a therapeutic avenue for AD by modulating the activity of APP.
Conclusion: Our article employs bibliometric methods to unveil trends in research related to AD and TMS, including collaborations among countries, regions, and authors, as well as key research hotspots. We provide objective data that serves as a reference for scientific research and clinical work concerning AD and TMS.
期刊介绍：
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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