{"title":"亲电性硒驱动电子泄漏","authors":"Ruyi Zhou , Jicheng Yu , Zhen Gu","doi":"10.1016/j.chempr.2025.102499","DOIUrl":null,"url":null,"abstract":"<div><div>Disrupting redox homeostasis in cancer cells represents a promising strategy for minimizing toxicity and improving chemotherapy outcomes. In <em>Cell Biomaterials</em>, Chen, Ma, and colleagues describe an approach that employs a selenium electrophilic center with rapid electron-shuttle properties to boost mitochondrial electron leakage and thus convert antioxidants into pro-oxidants for cancer therapy.</div></div>","PeriodicalId":268,"journal":{"name":"Chem","volume":"11 4","pages":"Article 102499"},"PeriodicalIF":19.6000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Electrophilic selenium drives electron leakage\",\"authors\":\"Ruyi Zhou , Jicheng Yu , Zhen Gu\",\"doi\":\"10.1016/j.chempr.2025.102499\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Disrupting redox homeostasis in cancer cells represents a promising strategy for minimizing toxicity and improving chemotherapy outcomes. In <em>Cell Biomaterials</em>, Chen, Ma, and colleagues describe an approach that employs a selenium electrophilic center with rapid electron-shuttle properties to boost mitochondrial electron leakage and thus convert antioxidants into pro-oxidants for cancer therapy.</div></div>\",\"PeriodicalId\":268,\"journal\":{\"name\":\"Chem\",\"volume\":\"11 4\",\"pages\":\"Article 102499\"},\"PeriodicalIF\":19.6000,\"publicationDate\":\"2025-04-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chem\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2451929425000890\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chem","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451929425000890","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/17 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Disrupting redox homeostasis in cancer cells represents a promising strategy for minimizing toxicity and improving chemotherapy outcomes. In Cell Biomaterials, Chen, Ma, and colleagues describe an approach that employs a selenium electrophilic center with rapid electron-shuttle properties to boost mitochondrial electron leakage and thus convert antioxidants into pro-oxidants for cancer therapy.
期刊介绍：
Chem, affiliated with Cell as its sister journal, serves as a platform for groundbreaking research and illustrates how fundamental inquiries in chemistry and its related fields can contribute to addressing future global challenges. It was established in 2016, and is currently edited by Robert Eagling.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
