Pub Date : 2025-01-17DOI: 10.1016/j.chempr.2024.102403
Daliang Han, Feifei Wang, Quan-Hong Yang
Invitation of organic cosolvents into aqueous electrolytes has been widely proven effective in stabilizing zinc (Zn) anodes but easily brings about sluggish desolvation kinetics concurrently. In this issue of Chem, Geng and coworkers report an organic/aqueous hybrid electrolyte with an organic-solvent-free primary solvation sheath, achieving facile desolvation and durable Zn batteries under subzero conditions.
{"title":"Cold-resilient zinc batteries with organic-free solvation structures","authors":"Daliang Han, Feifei Wang, Quan-Hong Yang","doi":"10.1016/j.chempr.2024.102403","DOIUrl":"https://doi.org/10.1016/j.chempr.2024.102403","url":null,"abstract":"Invitation of organic cosolvents into aqueous electrolytes has been widely proven effective in stabilizing zinc (Zn) anodes but easily brings about sluggish desolvation kinetics concurrently. In this issue of <em>Chem</em>, Geng and coworkers report an organic/aqueous hybrid electrolyte with an organic-solvent-free primary solvation sheath, achieving facile desolvation and durable Zn batteries under subzero conditions.","PeriodicalId":268,"journal":{"name":"Chem","volume":"43 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1016/j.chempr.2024.102389
Ali Omidkar, Avinash Alagumalai, Razieh Es’haghian, Hua Song
Producing clean, high-calorific fuels is challenging because of poor bio-oil quality, low yields, high costs, and environmental impacts. A new upgrading plant using methane instead of hydrogen offers a promising solution to address these issues effectively and sustainably.
{"title":"Producing economically viable renewable diesel by upgrading organic solid waste with natural gas","authors":"Ali Omidkar, Avinash Alagumalai, Razieh Es’haghian, Hua Song","doi":"10.1016/j.chempr.2024.102389","DOIUrl":"https://doi.org/10.1016/j.chempr.2024.102389","url":null,"abstract":"Producing clean, high-calorific fuels is challenging because of poor bio-oil quality, low yields, high costs, and environmental impacts. A new upgrading plant using methane instead of hydrogen offers a promising solution to address these issues effectively and sustainably.","PeriodicalId":268,"journal":{"name":"Chem","volume":"13 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-13DOI: 10.1016/j.chempr.2024.12.004
Shijie Deng, Hyuk-Joon Jung, Yi Shen, Hootan Roshandel, Varit Chantranuwathana, Hieu D. Nguyen, Thi V. Tran, Kimberly Vasquez, Joseph Chang, Takeo Iwase, Parisa Mehrkhodavandi, Jeffery A. Byers, Loi H. Do, Paula L. Diaconescu
Among major engineering plastics, aromatic polyamides are high-performance materials with high mechanical strength and heat resistance. However, the production of these materials is limited to para- and meta-aromatic polyamides via polycondensation, leading to polymers with low molecular weight and high dispersity. Here, we report the ring-opening polymerization of N-alkylated aromatic 6-membered-ring N-carboxyanhydrides (6-NCA-R) catalyzed by transition-metal Schiff base complexes in the presence of a base. This system allows the facile synthesis of ortho-aromatic polyamides with high molecular weights via chain-growth polymerization. We propose a mechanism on the basis of the results of polymerizations performed under various reaction conditions. In addition, we show the tunability of polymer solubility and thermal properties by varying the length of N-alkyl side chains and perform copolymerization of 6-NCA-R with heterocyclic monomers to prepare heteroatom-containing copolymers. These findings provide a synthetic pathway for functional polyamide materials with tailored properties for various applications.
{"title":"ortho-Aromatic polyamides by ring-opening polymerization of N-carboxyanhydrides","authors":"Shijie Deng, Hyuk-Joon Jung, Yi Shen, Hootan Roshandel, Varit Chantranuwathana, Hieu D. Nguyen, Thi V. Tran, Kimberly Vasquez, Joseph Chang, Takeo Iwase, Parisa Mehrkhodavandi, Jeffery A. Byers, Loi H. Do, Paula L. Diaconescu","doi":"10.1016/j.chempr.2024.12.004","DOIUrl":"https://doi.org/10.1016/j.chempr.2024.12.004","url":null,"abstract":"Among major engineering plastics, aromatic polyamides are high-performance materials with high mechanical strength and heat resistance. However, the production of these materials is limited to <em>para</em>- and <em>meta</em>-aromatic polyamides via polycondensation, leading to polymers with low molecular weight and high dispersity. Here, we report the ring-opening polymerization of <em>N</em>-alkylated aromatic 6-membered-ring <em>N</em>-carboxyanhydrides (6-NCA-R) catalyzed by transition-metal Schiff base complexes in the presence of a base. This system allows the facile synthesis of <em>ortho</em>-aromatic polyamides with high molecular weights via chain-growth polymerization. We propose a mechanism on the basis of the results of polymerizations performed under various reaction conditions. In addition, we show the tunability of polymer solubility and thermal properties by varying the length of <em>N</em>-alkyl side chains and perform copolymerization of 6-NCA-R with heterocyclic monomers to prepare heteroatom-containing copolymers. These findings provide a synthetic pathway for functional polyamide materials with tailored properties for various applications.","PeriodicalId":268,"journal":{"name":"Chem","volume":"204 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1016/j.chempr.2024.12.002
Xiao Jia, Dan Yang, Dexu Zheng, Zhen Chang, Jishuang Liu, Lu Liu, Lei Peng, Yao Tong, Kai Wang, Shengzhong Liu
The lead-based single-junction perovskite solar cells have achieved impressive efficiencies of up to 26.8%, highlighting their remarkable application potential and driving rapid advancements in large-area modules. However, as efficiencies approach the Shockley-Queisser limit for single-junction cells, further advancements are becoming increasingly challenging. Consequently, researchers have shifted their focus toward tin-lead alloyed perovskite (TLP) materials, aiming to construct multi-junction tandems. Recent advancements in both single-junction and multi-junction perovskite solar cells underscore the vast potential of TLPs, and their continued development promises a novel avenue for the industrialization of perovskite technology. This review provides a comprehensive overview of recent advancements in TLPs for photovoltaic applications, covering ionic compositions, crystallization engineering, modifications of extrinsic substances, and contact layers. It also discusses progress in multi-junction tandems and large-scale modules, providing valuable insights for commercial production. The review concludes by summarizing the overall progress in TLPs and providing a perspective on future research.
{"title":"The progress and challenges of tin-lead alloyed perovskites: Toward the development of large-scale all-perovskite tandem solar cells","authors":"Xiao Jia, Dan Yang, Dexu Zheng, Zhen Chang, Jishuang Liu, Lu Liu, Lei Peng, Yao Tong, Kai Wang, Shengzhong Liu","doi":"10.1016/j.chempr.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.chempr.2024.12.002","url":null,"abstract":"The lead-based single-junction perovskite solar cells have achieved impressive efficiencies of up to 26.8%, highlighting their remarkable application potential and driving rapid advancements in large-area modules. However, as efficiencies approach the Shockley-Queisser limit for single-junction cells, further advancements are becoming increasingly challenging. Consequently, researchers have shifted their focus toward tin-lead alloyed perovskite (TLP) materials, aiming to construct multi-junction tandems. Recent advancements in both single-junction and multi-junction perovskite solar cells underscore the vast potential of TLPs, and their continued development promises a novel avenue for the industrialization of perovskite technology. This review provides a comprehensive overview of recent advancements in TLPs for photovoltaic applications, covering ionic compositions, crystallization engineering, modifications of extrinsic substances, and contact layers. It also discusses progress in multi-junction tandems and large-scale modules, providing valuable insights for commercial production. The review concludes by summarizing the overall progress in TLPs and providing a perspective on future research.","PeriodicalId":268,"journal":{"name":"Chem","volume":"44 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renewable energy-driven heterogeneous electrocatalysis holds tremendous potential in converting earth-abundant small molecules and industrial pollutants into value-added or environmentally friendly chemicals, sparking global research interest. The catalyst-electrolyte interface has long been at the forefront of heterogeneous electrocatalysis, dealing with the structure-performance relationship between the performance and the catalytic system, consisting of catalysts, electrolytes, and external biases, at the molecular or atomic level. However, recent observations of numerous surface reconstruction phenomena have challenged the traditional research paradigm that relies on static interface models to elucidate structure-performance relationships. This perspective focuses on the catalyst-electrolyte interface model and rationalizes the underlying principles of catalyst surface reconstruction behavior in terms of free energy. It then showcases the influence of pre-catalyst structure, electrolyte (including additives and reaction intermediates), and external bias on surface reconstruction, alongside state-of-the-art modulation strategies based on the current understanding of surface construction. Finally, we highlight critical issues for future research on catalyst surface reconstruction, including the unexplored factors influencing reconstruction and reaction types, the necessary developments in in situ characterization and simulation techniques, and the currently overlooked problem of catalyst deactivation.
{"title":"In-depth understanding and precise modulation of surface reconstruction during heterogeneous electrocatalysis: From model to practical catalyst","authors":"Weidong Dai, Kaiwei Wan, Kanglei Pang, Jun Guo, Siyuan Liu, Keying Wu, Chiyao Tang, Yanjuan Sun, Xinghua Shi, Zhiyong Tang, Chang Long, Fan Dong","doi":"10.1016/j.chempr.2024.10.012","DOIUrl":"https://doi.org/10.1016/j.chempr.2024.10.012","url":null,"abstract":"Renewable energy-driven heterogeneous electrocatalysis holds tremendous potential in converting earth-abundant small molecules and industrial pollutants into value-added or environmentally friendly chemicals, sparking global research interest. The catalyst-electrolyte interface has long been at the forefront of heterogeneous electrocatalysis, dealing with the structure-performance relationship between the performance and the catalytic system, consisting of catalysts, electrolytes, and external biases, at the molecular or atomic level. However, recent observations of numerous surface reconstruction phenomena have challenged the traditional research paradigm that relies on static interface models to elucidate structure-performance relationships. This perspective focuses on the catalyst-electrolyte interface model and rationalizes the underlying principles of catalyst surface reconstruction behavior in terms of free energy. It then showcases the influence of pre-catalyst structure, electrolyte (including additives and reaction intermediates), and external bias on surface reconstruction, alongside state-of-the-art modulation strategies based on the current understanding of surface construction. Finally, we highlight critical issues for future research on catalyst surface reconstruction, including the unexplored factors influencing reconstruction and reaction types, the necessary developments in <em>in situ</em> characterization and simulation techniques, and the currently overlooked problem of catalyst deactivation.","PeriodicalId":268,"journal":{"name":"Chem","volume":"204 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-08DOI: 10.1016/j.chempr.2024.12.001
Wenxuan Sun, Zengguang Li, Wei Guo, Yongzhu Fu
Interface chemistry inevitably affects Zn dendrite formation and interfacial kinetics, which pose serious challenges in zinc metal batteries (ZMBs). In the December issue of Chem, Guo et al. identified that Zn2+ transport in the solid electrolyte interphases (SEIs) is the rate-limiting step of Zn2+ transfer kinetics in typical ZMBs and designed a SEI comprising Zn3N2 species, thereby overcoming the above-mentioned issues.
{"title":"The key of Zn2+ transfer kinetics in zinc metal batteries","authors":"Wenxuan Sun, Zengguang Li, Wei Guo, Yongzhu Fu","doi":"10.1016/j.chempr.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.chempr.2024.12.001","url":null,"abstract":"Interface chemistry inevitably affects Zn dendrite formation and interfacial kinetics, which pose serious challenges in zinc metal batteries (ZMBs). In the December issue of <em>Chem</em>, Guo et al. identified that Zn<sup>2+</sup> transport in the solid electrolyte interphases (SEIs) is the rate-limiting step of Zn<sup>2+</sup> transfer kinetics in typical ZMBs and designed a SEI comprising Zn<sub>3</sub>N<sub>2</sub> species, thereby overcoming the above-mentioned issues.","PeriodicalId":268,"journal":{"name":"Chem","volume":"28 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142936138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-08DOI: 10.1016/j.chempr.2024.11.017
Ananya Mishra, Avinash J. Patil, Stephen Mann
The construction of biomimetic agents capable of generating precise outcomes in response to specific molecular inputs is a central challenge for the development of programmable synthetic cells with integrated biomimetic functions. Here, we harness acoustic standing waves to generate periodic microarrays of enzyme-encoded coacervate microdroplets for the implementation of embodied enzyme logic circuits (EELCs). We describe a range of biocatalytic communication channels capable of performing localized and distributed Boolean logic functions in single or segregated populations of model protocells by using a range of molecular inputs, fluorescence or hydrogelation outputs, and programmable response dynamics. To implement long-range collective signal processing, we integrate EELC modules across spatially segregated protocell populations to generate distributed time-regulated logic operations involving negative feedback, pulse generation, and redirected output-input connectivity. Our results provide a step toward the non-DNA programming of model protocell communication and computational networks for miniaturized autonomous sensing devices capable of chemical-based information processing.
{"title":"Biocatalytic programming of protocell-embodied logic gates and circuits","authors":"Ananya Mishra, Avinash J. Patil, Stephen Mann","doi":"10.1016/j.chempr.2024.11.017","DOIUrl":"https://doi.org/10.1016/j.chempr.2024.11.017","url":null,"abstract":"The construction of biomimetic agents capable of generating precise outcomes in response to specific molecular inputs is a central challenge for the development of programmable synthetic cells with integrated biomimetic functions. Here, we harness acoustic standing waves to generate periodic microarrays of enzyme-encoded coacervate microdroplets for the implementation of embodied enzyme logic circuits (EELCs). We describe a range of biocatalytic communication channels capable of performing localized and distributed Boolean logic functions in single or segregated populations of model protocells by using a range of molecular inputs, fluorescence or hydrogelation outputs, and programmable response dynamics. To implement long-range collective signal processing, we integrate EELC modules across spatially segregated protocell populations to generate distributed time-regulated logic operations involving negative feedback, pulse generation, and redirected output-input connectivity. Our results provide a step toward the non-DNA programming of model protocell communication and computational networks for miniaturized autonomous sensing devices capable of chemical-based information processing.","PeriodicalId":268,"journal":{"name":"Chem","volume":"56 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142936132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-06DOI: 10.1016/j.chempr.2024.12.003
Elwy H. Abdelkader, Haocheng Qianzhu, Gottfried Otting, Thomas Huber
Few chemistries are suitable for in-cell protein labeling, and the required reagents are costly. We present an approach for the coupled biosynthesis and genetic encoding of activated nitriles, delivering a facile way to furnish proteins with biocompatible reactive handles suitable for subsequent site-specific modifications both in cell and in vitro. The strategy utilizes the endogenous bacterial cysteine biosynthetic machinery to produce the nitrile-bearing non-canonical amino acids (ncAAs) in situ and then perform genetic encoding through an engineered orthogonal translation system. We demonstrate the utility of our system for rapid site-specific bioconjugation and macrocyclization through the nitrile-aminothiol (NAT) click reaction. In addition, we introduce the aromatic condensation NAT (arcNAT) click reaction as a tool for generating a diverse array of turn-on fluorophores. arcNAT achieves fluorogenic labeling of proteins for live-cell microscopy without requiring washing steps. Our approach provides a uniquely convenient, versatile, and cost-effective platform for the post-translational diversification of proteins.
{"title":"Biosynthesis and genetic encoding of activated nitriles for fast protein conjugation and tunable fluorogenic labeling","authors":"Elwy H. Abdelkader, Haocheng Qianzhu, Gottfried Otting, Thomas Huber","doi":"10.1016/j.chempr.2024.12.003","DOIUrl":"https://doi.org/10.1016/j.chempr.2024.12.003","url":null,"abstract":"Few chemistries are suitable for in-cell protein labeling, and the required reagents are costly. We present an approach for the coupled biosynthesis and genetic encoding of activated nitriles, delivering a facile way to furnish proteins with biocompatible reactive handles suitable for subsequent site-specific modifications both in cell and <em>in vitro</em>. The strategy utilizes the endogenous bacterial cysteine biosynthetic machinery to produce the nitrile-bearing non-canonical amino acids (ncAAs) <em>in situ</em> and then perform genetic encoding through an engineered orthogonal translation system. We demonstrate the utility of our system for rapid site-specific bioconjugation and macrocyclization through the nitrile-aminothiol (NAT) click reaction. In addition, we introduce the aromatic condensation NAT (arcNAT) click reaction as a tool for generating a diverse array of turn-on fluorophores. arcNAT achieves fluorogenic labeling of proteins for live-cell microscopy without requiring washing steps. Our approach provides a uniquely convenient, versatile, and cost-effective platform for the post-translational diversification of proteins.","PeriodicalId":268,"journal":{"name":"Chem","volume":"4 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-03DOI: 10.1016/j.chempr.2024.11.019
Na Chen, Jing Xi, Tianpei He, Ruichen Shen, Rui Zhao, Haoming Chi, Jia Yao, Na Du, Lilei Yu, Yun Zhang, Tianyou Peng, Tiangang Liu, Quan Yuan
Inspired by the solar energy storage process during photosynthesis, we report herein a solar-decoupled photosynthetic biohybrid strategy through integrating a persistent photocatalyst with photoautotrophic microbes for sustainable and all-weather biomanufacturing, allowing for overcoming the intrinsic intermittent nature of solar energy availability by introducing energy storage and release processes. The results demonstrate that the apparent photo conversion efficiency (APCE) for of the persistent catalyst/R. palustris hybrid system reaches 8.30%, much higher than the 4.36% observed in bare R. palustris. Additionally, the proposed solar-decoupled biohybrid strategy not only shows considerable potential in coupling the practical power plant for the capture and utilization of CO2 from the flue gas but also exhibits universal applicability in different photosynthetic microorganisms. This concept-proving research offers new ideas to extend photocatalysis reactions without in situ irradiation and could pave new ways for sustainable solar energy utilization as well as biomanufacturing in space, where solar energy might be limited.
{"title":"Beyond natural synthesis via solar-decoupled biohybrid photosynthetic system","authors":"Na Chen, Jing Xi, Tianpei He, Ruichen Shen, Rui Zhao, Haoming Chi, Jia Yao, Na Du, Lilei Yu, Yun Zhang, Tianyou Peng, Tiangang Liu, Quan Yuan","doi":"10.1016/j.chempr.2024.11.019","DOIUrl":"https://doi.org/10.1016/j.chempr.2024.11.019","url":null,"abstract":"Inspired by the solar energy storage process during photosynthesis, we report herein a solar-decoupled photosynthetic biohybrid strategy through integrating a persistent photocatalyst with photoautotrophic microbes for sustainable and all-weather biomanufacturing, allowing for overcoming the intrinsic intermittent nature of solar energy availability by introducing energy storage and release processes. The results demonstrate that the apparent photo conversion efficiency (APCE) for of the persistent catalyst/<em>R</em>. <em>palustris</em> hybrid system reaches 8.30%, much higher than the 4.36% observed in bare <em>R. palustris</em>. Additionally, the proposed solar-decoupled biohybrid strategy not only shows considerable potential in coupling the practical power plant for the capture and utilization of CO<sub>2</sub> from the flue gas but also exhibits universal applicability in different photosynthetic microorganisms. This concept-proving research offers new ideas to extend photocatalysis reactions without <em>in situ</em> irradiation and could pave new ways for sustainable solar energy utilization as well as biomanufacturing in space, where solar energy might be limited.","PeriodicalId":268,"journal":{"name":"Chem","volume":"32 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-03DOI: 10.1016/j.chempr.2024.102394
Jennifer Ruth Hiscock
In this issue of Chem, Gale and co-workers bring together multiple fundamental supramolecular and medicinal chemistry principles to overcome the limitations associated with synthetic anion transporter technologies. These researchers report systems that are more active than those found in nature, alonside systems that can selectively target organelle membranes.
{"title":"Overcoming key challenges: Next-generation synthetic anion transporters","authors":"Jennifer Ruth Hiscock","doi":"10.1016/j.chempr.2024.102394","DOIUrl":"https://doi.org/10.1016/j.chempr.2024.102394","url":null,"abstract":"In this issue of <em>Chem</em>, Gale and co-workers bring together multiple fundamental supramolecular and medicinal chemistry principles to overcome the limitations associated with synthetic anion transporter technologies. These researchers report systems that are more active than those found in nature, alonside systems that can selectively target organelle membranes.","PeriodicalId":268,"journal":{"name":"Chem","volume":"2 1","pages":""},"PeriodicalIF":23.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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