S. Mancon , A. Matsukawa , A. Cadenar , I. Tsuboi , M. Miszczyk , M.K. Parizi , T. Fazekas , R.J. Schulz , A. Cormio , E. Laukhtina , A. Gallioli , P. Diana , R. Contieri , F. Soria , B. Pradere , G. Lughezzani , T. Kimura , A. Territo , A. Breda , N.M. Buffi , D. D’Andrea
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A meta-analysis was performed to calculate the pooled risk ratio (RR) with 95% confidence intervals (CIs) (PROSPERO: CRD42024562623).</div></div><div><h3>Results</h3><div>A total of 15 studies (n<!--> <!-->=<!--> <!-->60,149) were included. The analysis showed that opium users had a significantly higher risk of developing BCa than non-users (RR: 2.36; 95% CI: 1.92–2.90; <em>P</em> <!--><<!--> <!-->.001). The risk increased with the amount of opium consumed, regardless of type or method of use.</div></div><div><h3>Conclusions</h3><div>Opium consumption increase the risk of developing BCa by more than twofold among users. Awareness of its carcinogenic potential and public health implications is crucial. 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D’Andrea\",\"doi\":\"10.1016/j.acuroe.2025.501749\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Opium is used recreationally and for pain relief in certain regions and has been classified as a human carcinogen by the IARC. While its use is rare in Europe and Oceania, it remains a major public health issue in other parts of the world. This study evaluates the risk of bladder cancer (BCa) among opium users compared to non-users.</div></div><div><h3>Methods</h3><div>A comprehensive search of MEDLINE, Scopus, and Web of Science was conducted up to July 2024 to identify studies examining the link between opium use and BCa. A meta-analysis was performed to calculate the pooled risk ratio (RR) with 95% confidence intervals (CIs) (PROSPERO: CRD42024562623).</div></div><div><h3>Results</h3><div>A total of 15 studies (n<!--> <!-->=<!--> <!-->60,149) were included. 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引用次数: 0
摘要
简介：鸦片在某些地区用于娱乐和止痛，并已被国际癌症研究机构列为人类致癌物。虽然在欧洲和大洋洲很少使用，但在世界其他地区，它仍然是一个重大的公共卫生问题。本研究评估了鸦片使用者与非使用者之间膀胱癌（BCa）的风险。方法：到2024年7月，对MEDLINE、Scopus和Web of Science进行综合检索，以确定有关鸦片使用与BCa之间联系的研究。采用荟萃分析计算95%置信区间（ci）的合并风险比（RR） （PROSPERO: CRD42024562623）。结果：共纳入15项研究（n = 60149）。分析表明，鸦片使用者发生BCa的风险明显高于非使用者(RR: 2.36；95% ci: 1.92-2.90；p结论：鸦片消费使使用者患BCa的风险增加了两倍以上。对其潜在致癌性和公共卫生影响的认识至关重要。我们的研究结果强调需要制定全球预防战略，并进一步研究与鸦片有关的BCa风险。
Impact of opium on bladder cancer incidence: A systematic review and meta-analysis
Introduction
Opium is used recreationally and for pain relief in certain regions and has been classified as a human carcinogen by the IARC. While its use is rare in Europe and Oceania, it remains a major public health issue in other parts of the world. This study evaluates the risk of bladder cancer (BCa) among opium users compared to non-users.
Methods
A comprehensive search of MEDLINE, Scopus, and Web of Science was conducted up to July 2024 to identify studies examining the link between opium use and BCa. A meta-analysis was performed to calculate the pooled risk ratio (RR) with 95% confidence intervals (CIs) (PROSPERO: CRD42024562623).
Results
A total of 15 studies (n = 60,149) were included. The analysis showed that opium users had a significantly higher risk of developing BCa than non-users (RR: 2.36; 95% CI: 1.92–2.90; P < .001). The risk increased with the amount of opium consumed, regardless of type or method of use.
Conclusions
Opium consumption increase the risk of developing BCa by more than twofold among users. Awareness of its carcinogenic potential and public health implications is crucial. Our findings underscore the need for global prevention strategies and further research into opium-related BCa risks.
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