首页 > 最新文献

Actas urologicas espanolas最新文献

英文 中文
Long term outcomes from uncorrected hypospadias: a scoping review. 尿道下裂未矫正的长期后果:范围界定综述。
Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1016/j.acuroe.2024.10.004
E Bohane, M Murphy, F Chierigo, G Mantica, J Adamowicz, F Campos-Juanatey, A Cocci, M Frankiewicz, C M Rosenbaum, W Verla, M Waterloos, Ł Białek, F X Madec, M Oszczudłowski, M W Vetterlein, E J Redmond

Introduction: The goal of hypospadias repair is to optimize urinary and sexual function, improve cosmesis and minimise the psychosocial effects associated with a penile anomaly. However, a lack of clarity exists regarding the role of surgery in milder hypospadias where the anomaly is inconspicuous and there is no anticipated impact on function. The aim of this study was to review the long term functional, cosmetic and psychosocial outcomes in men with uncorrected hypospadias. This information may be helpful for parents who are burdened with deciding the correct treatment for their child's hypospadias.

Methods: A scoping review of PubMed, EMBASE, and CINAHL + databases was performed in adherence with PRISMA guidelines. Eight studies were identified for inclusion in the review.

Results: Men with mild uncorrected hypospadias have similar functional outcomes to those without hypospadias, preferring to void standing and reporting similar IPSS scores. However, those with severe untreated hypospadias experience significant urinary difficulties, higher IPSS scores, and are more likely to sit when voiding. They reported worse SHIM scores, more ventral curvature, and greater difficulty with intercourse. Most men with incidentally identified hypospadias are unaware of their condition and are satisfied with their penile appearance. There was no difference in the attainment of psychosocial milestones between men with uncorrected hypospadias versus no hypospadias.

Conclusion: There is a lack of research regarding the experiences of adult men with uncorrected hypospadias. However, there is some evidence to support the non-operative management of mild hypospadias. Therefore, the decision to defer surgery in infancy should balance parental wishes and physician guidance, particularly in cases where the risk of functional impairment is low.

导言:尿道下裂修复术的目的是优化排尿和性功能,改善外观,尽量减少阴茎畸形带来的社会心理影响。然而,在尿道下裂程度较轻、畸形不明显且预计不会影响功能的情况下,手术的作用尚不明确。本研究旨在回顾尿道下裂未矫正男性的长期功能、外观和社会心理影响。这些信息可能对那些为决定如何正确治疗尿道下裂而烦恼的父母有所帮助:方法:根据 PRISMA 指南,对 PubMed、EMBASE 和 CINAHL + 数据库进行了范围审查。结果:患有轻度尿道下裂而未矫正的男性,其尿道下裂程度较轻:结果:患有轻度未矫正尿道下裂的男性与无尿道下裂的男性具有相似的功能结果,他们更喜欢站立排尿,并报告了相似的IPSS评分。然而,那些患有严重尿道下裂且未得到治疗的患者会出现严重的排尿困难,IPSS评分较高,排尿时更倾向于坐着。他们的SHIM评分更差,腹侧弯曲更多,性交困难更大。大多数意外发现尿道下裂的男性并不知道自己的病情,并对自己的阴茎外观感到满意。未矫正尿道下裂的男性与未矫正尿道下裂的男性在达到社会心理里程碑方面没有差异:关于尿道下裂未矫正成年男性的经历,目前还缺乏相关研究。不过,有一些证据支持对轻度尿道下裂进行非手术治疗。因此,在决定是否推迟婴儿期手术时,应平衡父母的意愿和医生的指导,尤其是在功能障碍风险较低的情况下。
{"title":"Long term outcomes from uncorrected hypospadias: a scoping review.","authors":"E Bohane, M Murphy, F Chierigo, G Mantica, J Adamowicz, F Campos-Juanatey, A Cocci, M Frankiewicz, C M Rosenbaum, W Verla, M Waterloos, Ł Białek, F X Madec, M Oszczudłowski, M W Vetterlein, E J Redmond","doi":"10.1016/j.acuroe.2024.10.004","DOIUrl":"10.1016/j.acuroe.2024.10.004","url":null,"abstract":"<p><strong>Introduction: </strong>The goal of hypospadias repair is to optimize urinary and sexual function, improve cosmesis and minimise the psychosocial effects associated with a penile anomaly. However, a lack of clarity exists regarding the role of surgery in milder hypospadias where the anomaly is inconspicuous and there is no anticipated impact on function. The aim of this study was to review the long term functional, cosmetic and psychosocial outcomes in men with uncorrected hypospadias. This information may be helpful for parents who are burdened with deciding the correct treatment for their child's hypospadias.</p><p><strong>Methods: </strong>A scoping review of PubMed, EMBASE, and CINAHL + databases was performed in adherence with PRISMA guidelines. Eight studies were identified for inclusion in the review.</p><p><strong>Results: </strong>Men with mild uncorrected hypospadias have similar functional outcomes to those without hypospadias, preferring to void standing and reporting similar IPSS scores. However, those with severe untreated hypospadias experience significant urinary difficulties, higher IPSS scores, and are more likely to sit when voiding. They reported worse SHIM scores, more ventral curvature, and greater difficulty with intercourse. Most men with incidentally identified hypospadias are unaware of their condition and are satisfied with their penile appearance. There was no difference in the attainment of psychosocial milestones between men with uncorrected hypospadias versus no hypospadias.</p><p><strong>Conclusion: </strong>There is a lack of research regarding the experiences of adult men with uncorrected hypospadias. However, there is some evidence to support the non-operative management of mild hypospadias. Therefore, the decision to defer surgery in infancy should balance parental wishes and physician guidance, particularly in cases where the risk of functional impairment is low.</p>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cosmetic complications after anterior urethral surgery: a scoping review and photo collection. 前尿道手术后的美容并发症:范围综述和图片集。
Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1016/j.acuroe.2024.12.002
F Chierigo, G Mantica, G Drocchi, F X Madec, W Verla, Ł Białek, J Adamowicz, A Cocci, M Frankiewicz, J Klemm, P Neuville, M Oszczudłowski, E J Redmond, C M Rosenbaum, M Waterloos, M W Vetterlein, F Campos-Juanatey

Introduction: Anterior urethroplasty is the gold standard for treating complex urethral strictures, primarily focusing on restoring urinary function. However, aesthetic complications, including penile curvature, scarring, and meatal deformities, can impact patient satisfaction, self-image, and quality of life. Despite their significance, cosmetic outcomes are underreported in the literature, affecting patient counseling and surgical planning.

Objective: This scoping review aims to assess the prevalence, types, and contributing factors of cosmetic complications after anterior urethroplasty. A photographic collection of these complications is also presented to aid in clinical education.

Materials and methods: A systematic search of PubMed, Scopus, and Web of Science databases was performed, including studies from 2000 onward that report cosmetic outcomes in male adult patients post-urethroplasty. Following PRISMA guidelines, studies focusing on pediatric cases, case reports with fewer than 10 patients, and those lacking specific cosmetic data were excluded.

Results: Of the 493 studies screened, 97 met the inclusion criteria, with only a minority (8 studies) explicitly discussing cosmetic complications. Reported issues varied widely, including penile curvature, skin tethering, hypertrophic scarring, meatal deformities, and penile shortening, underscoring the diversity of aesthetic challenges in urethral reconstruction.

Conclusion: This review highlights the need for incorporating aesthetic considerations into surgical planning and patient counseling for anterior urethroplasty. Standardized metrics for evaluating cosmetic outcomes could improve patient satisfaction and the quality of care in urethral reconstruction.

导言:前路尿道成形术是治疗复杂尿道狭窄的金标准,主要侧重于恢复泌尿功能。然而,美学并发症,包括阴茎弯曲、疤痕和金属畸形,会影响患者的满意度、自我形象和生活质量。尽管其重要性,美容结果在文献中被低估,影响患者咨询和手术计划。目的:本综述旨在评估前路尿道成形术后美容并发症的发生率、类型和影响因素。这些并发症的摄影集也提出,以帮助临床教育。材料和方法:对PubMed、Scopus和Web of Science数据库进行系统检索,包括2000年以来报告男性成年患者尿道成形术后美容结果的研究。根据PRISMA指南,针对儿科病例的研究、少于10例患者的病例报告以及缺乏特定美容数据的研究被排除在外。结果:在筛选的493项研究中,97项符合纳入标准,只有少数(8项研究)明确讨论了美容并发症。报道的问题各不相同,包括阴茎弯曲、皮肤栓系、肥厚性瘢痕、金属畸形和阴茎缩短,强调了尿道重建中美学挑战的多样性。结论:本综述强调了将美学考虑纳入前路尿道成形术的手术计划和患者咨询的必要性。评估美容结果的标准化指标可以提高患者满意度和尿道重建的护理质量。
{"title":"Cosmetic complications after anterior urethral surgery: a scoping review and photo collection.","authors":"F Chierigo, G Mantica, G Drocchi, F X Madec, W Verla, Ł Białek, J Adamowicz, A Cocci, M Frankiewicz, J Klemm, P Neuville, M Oszczudłowski, E J Redmond, C M Rosenbaum, M Waterloos, M W Vetterlein, F Campos-Juanatey","doi":"10.1016/j.acuroe.2024.12.002","DOIUrl":"10.1016/j.acuroe.2024.12.002","url":null,"abstract":"<p><strong>Introduction: </strong>Anterior urethroplasty is the gold standard for treating complex urethral strictures, primarily focusing on restoring urinary function. However, aesthetic complications, including penile curvature, scarring, and meatal deformities, can impact patient satisfaction, self-image, and quality of life. Despite their significance, cosmetic outcomes are underreported in the literature, affecting patient counseling and surgical planning.</p><p><strong>Objective: </strong>This scoping review aims to assess the prevalence, types, and contributing factors of cosmetic complications after anterior urethroplasty. A photographic collection of these complications is also presented to aid in clinical education.</p><p><strong>Materials and methods: </strong>A systematic search of PubMed, Scopus, and Web of Science databases was performed, including studies from 2000 onward that report cosmetic outcomes in male adult patients post-urethroplasty. Following PRISMA guidelines, studies focusing on pediatric cases, case reports with fewer than 10 patients, and those lacking specific cosmetic data were excluded.</p><p><strong>Results: </strong>Of the 493 studies screened, 97 met the inclusion criteria, with only a minority (8 studies) explicitly discussing cosmetic complications. Reported issues varied widely, including penile curvature, skin tethering, hypertrophic scarring, meatal deformities, and penile shortening, underscoring the diversity of aesthetic challenges in urethral reconstruction.</p><p><strong>Conclusion: </strong>This review highlights the need for incorporating aesthetic considerations into surgical planning and patient counseling for anterior urethroplasty. Standardized metrics for evaluating cosmetic outcomes could improve patient satisfaction and the quality of care in urethral reconstruction.</p>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":" ","pages":"42-62"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
History of urethral surgery: Lessons learnt from the past. 尿道手术的历史:从过去吸取的教训。
Pub Date : 2024-12-19 DOI: 10.1016/j.acuroe.2024.12.003
F X Madec, P Neuville, F Chierigo, J Adamowicz, Ł Białek, A Cocci, M Frankiewicz, G Mantica, M Oszczudłowski, E J Redmond, C M Rosenbaum, W Verla, M Waterloos, F Campos-Juanatey, J Klemm, M Vetterlein

Introduction: Although failures are undesirable, they offer valuable learning opportunities that drive progress through necessary changes. This concept holds particularly true in the history of urethral reconstruction.

Methods: A comprehensive literature review was conducted using PubMed, focusing on the history of the urethral stricture and current trends based on national and international guidelines for urethral stricture management.

Results: Urethral strictures are among the oldest known urological conditions, with initial treatments centred around dilatation. These palliative measures proved disappointing. The advent of reconstructive urology has transformed this pathology into a treatable condition, notably through Excision and Primary Anastomosis (EPA) and one-stage augmentation urethroplasty using buccal grafts.

Conclusion: Urethroplasty is the gold standard treatment for urethral strictures, and ongoing refinements aim to further reduce morbidity.

虽然失败是不受欢迎的,但它们提供了宝贵的学习机会,通过必要的改变推动进步。这个概念在尿道重建的历史上尤其正确。方法:结合国内外尿道狭窄治疗指南,在PubMed上进行文献综述,重点分析尿道狭窄的历史和发展趋势。结果:尿道狭窄是已知的最古老的泌尿系统疾病之一,最初的治疗以扩张为中心。事实证明,这些缓和措施令人失望。重建泌尿外科的出现已经将这种病理转变为一种可治疗的疾病,特别是通过切除和初级吻合(EPA)和一期增强尿道成形术使用颊移植物。结论:尿道成形术是尿道狭窄的金标准治疗方法,并不断改进以进一步降低发病率。
{"title":"History of urethral surgery: Lessons learnt from the past.","authors":"F X Madec, P Neuville, F Chierigo, J Adamowicz, Ł Białek, A Cocci, M Frankiewicz, G Mantica, M Oszczudłowski, E J Redmond, C M Rosenbaum, W Verla, M Waterloos, F Campos-Juanatey, J Klemm, M Vetterlein","doi":"10.1016/j.acuroe.2024.12.003","DOIUrl":"10.1016/j.acuroe.2024.12.003","url":null,"abstract":"<p><strong>Introduction: </strong>Although failures are undesirable, they offer valuable learning opportunities that drive progress through necessary changes. This concept holds particularly true in the history of urethral reconstruction.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted using PubMed, focusing on the history of the urethral stricture and current trends based on national and international guidelines for urethral stricture management.</p><p><strong>Results: </strong>Urethral strictures are among the oldest known urological conditions, with initial treatments centred around dilatation. These palliative measures proved disappointing. The advent of reconstructive urology has transformed this pathology into a treatable condition, notably through Excision and Primary Anastomosis (EPA) and one-stage augmentation urethroplasty using buccal grafts.</p><p><strong>Conclusion: </strong>Urethroplasty is the gold standard treatment for urethral strictures, and ongoing refinements aim to further reduce morbidity.</p>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of changes in sexual function in patients undergoing endoscopic surgery for upper urinary tract lithiasis 评估接受内窥镜手术治疗上尿路结石患者的性功能变化。
Pub Date : 2024-12-01 DOI: 10.1016/j.acuroe.2024.09.003
J. Tabares Jiménez, G. Bueno Serrano, M.P. Alcoba García, R. González López, B. Gómez Jordana, I. Mahillo Fernández, C. González Enguita

Objective

To evaluate the effect of endoscopic surgery on sexual function in patients with upper urinary tract (UUT) lithiasis.

Material and methods

We conducted an observational, prospective, longitudinal study with a single cohort of cases undergoing ureteroscopy (URS), retrograde intrarenal surgery (RIRS), or endoscopic combined intrarenal surgery (ECIRS). Patients' sexual response was assessed with questionnaires in the 30 days prior to surgery, and at one and three months after surgery. The International Index of Erectile Function (IIEF-t) was used in male patients, and the Female Sexual Function Index (FSFI) was used in female patients.

Results

Seventy patients – 34 men and 36 women – completed the study. Among men, the IIEF-t did not show significant difference between baseline scores (64.1 ± 7.50) and those obtained at 3 months (63.8 ± 9.51), with a non-significant decrease (p = 0.054) at the first month (61.4 ± 10.4). Subdomains did not worsen at 3 months, and desire (IIEF-SD) improved from 7.3 ± 1.9 to 8.0 ± 1.8. Among women, the FSFI-t did not change significantly after surgery: baseline score (27.3 ± 4.1), 1-month score (26.8 ± 3.7) and 3-month score (27.5 ± 4.2). No subdomain worsened at the third month.

Conclusion

Endoscopic surgery for UUT is a safe technique in both sexes with no negative effect on sexual function. There are no differences between the baseline IIEF-t and FSFI-t scores and those obtained at 3 months.
目的:评估内窥镜手术对上尿路结石(UUT)患者性功能的影响:评估内窥镜手术对上尿路(UUT)结石患者性功能的影响:我们对接受输尿管镜检查(URS)、逆行肾内手术(RIRS)或内镜联合肾内手术(ECIRS)的病例进行了一项观察性、前瞻性、纵向研究。在手术前30天、手术后1个月和3个月,对患者的性反应进行了问卷评估。男性患者采用国际勃起功能指数(IIEF-t),女性患者采用女性性功能指数(FSFI):共有 70 名患者完成了研究,其中男性 34 人,女性 36 人。在男性患者中,IIEF-t 的基线分数(64.1 ± 7.50)与 3 个月后的分数(63.8 ± 9.51)之间没有明显差异,第一个月的分数(61.4 ± 10.4)下降不明显(p = 0.054)。3 个月后,子域的情况没有恶化,欲望(IIEF-SD)从 7.3 ± 1.9 改善到 8.0 ± 1.8。在女性中,FSFI-t 在术后没有明显变化:基线分数(27.3 ± 4.1)、1 个月分数(26.8 ± 3.7)和 3 个月分数(27.5 ± 4.2)。结论:内窥镜手术治疗 UUT 是一种有效的方法:结论:内窥镜手术治疗 UUT 是一种安全的技术,对男女性功能均无负面影响。基线IIEF-t和FSFI-t评分与3个月时的评分没有差异。
{"title":"Assessment of changes in sexual function in patients undergoing endoscopic surgery for upper urinary tract lithiasis","authors":"J. Tabares Jiménez,&nbsp;G. Bueno Serrano,&nbsp;M.P. Alcoba García,&nbsp;R. González López,&nbsp;B. Gómez Jordana,&nbsp;I. Mahillo Fernández,&nbsp;C. González Enguita","doi":"10.1016/j.acuroe.2024.09.003","DOIUrl":"10.1016/j.acuroe.2024.09.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effect of endoscopic surgery on sexual function in patients with upper urinary tract (UUT) lithiasis.</div></div><div><h3>Material and methods</h3><div>We conducted an observational, prospective, longitudinal study with a single cohort of cases undergoing ureteroscopy (URS), retrograde intrarenal surgery (RIRS), or endoscopic combined intrarenal surgery (ECIRS). Patients' sexual response was assessed with questionnaires in the 30 days prior to surgery, and at one and three months after surgery. The International Index of Erectile Function (IIEF-t) was used in male patients, and the Female Sexual Function Index (FSFI) was used in female patients.</div></div><div><h3>Results</h3><div>Seventy patients – 34 men and 36 women – completed the study. Among men, the IIEF-t did not show significant difference between baseline scores (64.1 ± 7.50) and those obtained at 3 months (63.8 ± 9.51), with a non-significant decrease (p = 0.054) at the first month (61.4 ± 10.4). Subdomains did not worsen at 3 months, and desire (IIEF-SD) improved from 7.3 ± 1.9 to 8.0 ± 1.8. Among women, the FSFI-t did not change significantly after surgery: baseline score (27.3 ± 4.1), 1-month score (26.8 ± 3.7) and 3-month score (27.5 ± 4.2). No subdomain worsened at the third month.</div></div><div><h3>Conclusion</h3><div>Endoscopic surgery for UUT is a safe technique in both sexes with no negative effect on sexual function. There are no differences between the baseline IIEF-t and FSFI-t scores and those obtained at 3 months.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"48 10","pages":"Pages 688-694"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consensus document on the implications of standardization of BCG supply in the management of patients with non-muscle-invasive bladder cancer 卡介苗供应标准化对非肌层浸润性膀胱癌患者治疗的影响共识文件。
Pub Date : 2024-12-01 DOI: 10.1016/j.acuroe.2024.09.005
Ó. Rodríguez Faba , J.M. Fernández Gómez , F. Guerrero-Ramos , M. Álvarez-Maestro , M.J. Ledo Cepero , M. Unda Urzaiz , L. Martínez-Piñeiro , J.M. Cózar Olmo , J. Palou Redorta , J.L. Álvarez-Ossorio
Patients with non-muscle-invasive bladder cancer (NMIBC) in the intermediate and high-risk groups must receive adjuvant treatment with intravesical Bacillus Calmette–Guérin (BCG) following transurethral resection (TUR), as it reduces the risk of recurrence and presumably the risk of progression as well. Optimization of BCG efficacy is achieved by administering maintenance therapy. However, since many immunological aspects of the mechanism of action of BCG in the bladder remain unknown, the implementation of the optimal dose, number of instillations, strains and adequate maintenance regimen over the last decades has been heterogeneous. Additionally, this has hindered the interpretation of efficacy in terms of oncologic outcomes. This, together with the shortages of BCG in recent years, have forced scientific societies to adapt their clinical practice guidelines and modify their protocols of adjuvant treatment with BCG. This includes changes to strains, doses, and maintenance during this period of time. This consensus document evaluates the current status of adjuvant BCG treatment and the implications of BCG supply availability in the treatment of patients with NMIBC. It also addresses the implementation of novel therapies that will improve cancer prognosis and the quality of life of patients with NMIBC in the future.
非肌层浸润性膀胱癌(NMIBC)中、高危组患者必须在经尿道切除术(TUR)后接受膀胱内卡介苗(BCG)辅助治疗,因为它能降低复发风险,并可能降低病情恶化的风险。卡介苗疗效的优化是通过维持治疗来实现的。然而,由于卡介苗在膀胱中作用机制的许多免疫学方面仍然未知,因此在过去几十年中,最佳剂量、注射次数、菌株和适当的维持治疗方案的实施情况各不相同。此外,这也妨碍了从肿瘤结果的角度解释疗效。再加上近年来卡介苗短缺,迫使科学协会调整临床实践指南,修改卡介苗辅助治疗方案。这包括在此期间对菌株、剂量和维持量的改变。本共识文件评估了卡介苗辅助治疗的现状以及卡介苗供应情况对治疗 NMIBC 患者的影响。它还讨论了未来将改善癌症预后和 NMIBC 患者生活质量的新型疗法的实施情况。
{"title":"Consensus document on the implications of standardization of BCG supply in the management of patients with non-muscle-invasive bladder cancer","authors":"Ó. Rodríguez Faba ,&nbsp;J.M. Fernández Gómez ,&nbsp;F. Guerrero-Ramos ,&nbsp;M. Álvarez-Maestro ,&nbsp;M.J. Ledo Cepero ,&nbsp;M. Unda Urzaiz ,&nbsp;L. Martínez-Piñeiro ,&nbsp;J.M. Cózar Olmo ,&nbsp;J. Palou Redorta ,&nbsp;J.L. Álvarez-Ossorio","doi":"10.1016/j.acuroe.2024.09.005","DOIUrl":"10.1016/j.acuroe.2024.09.005","url":null,"abstract":"<div><div>Patients with non-muscle-invasive bladder cancer (NMIBC) in the intermediate and high-risk groups must receive adjuvant treatment with intravesical Bacillus Calmette–Guérin (BCG) following transurethral resection (TUR), as it reduces the risk of recurrence and presumably the risk of progression as well. Optimization of BCG efficacy is achieved by administering maintenance therapy. However, since many immunological aspects of the mechanism of action of BCG in the bladder remain unknown, the implementation of the optimal dose, number of instillations, strains and adequate maintenance regimen over the last decades has been heterogeneous. Additionally, this has hindered the interpretation of efficacy in terms of oncologic outcomes. This, together with the shortages of BCG in recent years, have forced scientific societies to adapt their clinical practice guidelines and modify their protocols of adjuvant treatment with BCG. This includes changes to strains, doses, and maintenance during this period of time. This consensus document evaluates the current status of adjuvant BCG treatment and the implications of BCG supply availability in the treatment of patients with NMIBC. It also addresses the implementation of novel therapies that will improve cancer prognosis and the quality of life of patients with NMIBC in the future.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"48 10","pages":"Pages 718-731"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical application of the UroLift® prostatic urethral lift in Spain: consensus on the treatment of lower urinary tract symptoms associated with urinary flow obstruction and secondary to benign prostatic hyperplasia (BPH) UroLift® 前列腺尿道提升术在西班牙的临床应用:关于治疗与尿流梗阻相关并继发于良性前列腺增生症 (BPH) 的下尿路症状的共识。
Pub Date : 2024-12-01 DOI: 10.1016/j.acuroe.2024.09.004
M. Fernández Arjona , L. López Martín , L.M. Herranz Fernández , B. Sinues Ojas , J.M. Campá Bortoló , J. Extramiana Cameno , E. López Alcina , I. Povo Martín , A. Budía Alba , G. Ordaz Jurado , J.M. Osca García , M. Perán Teruel , V. Gimeno Argente , A. Navarro Beltrán , J. Benejam Gual , Y.E. Hernández Martínez , C. González Enguita
Benign prostatic hyperplasia (BPH) is an increasingly common pathology in the adult male. BPH increases after the age of 40–45 years, and its management consumes an enormous amount of resources. The UroLift® System is an approved technology designed to treat lower urinary tract symptoms (LUTS) secondary to BPH and is used to perform the prostatic urethral lift (PUL) procedure. Various urology specialists in Spain with experience in PUL have prepared this consensus document. Endorsed by the Spanish Urology Association, its information is based on the most recent findings. The main objective of this document is to disseminate the consensus recommendations among all professionals treating patients with LUTS/BPH. Both primary care physicians and urologists can assess and offer PUL as an effective, minimally invasive treatment.
良性前列腺增生症(BPH)在成年男性中越来越常见。良性前列腺增生症患者在 40-45 岁后逐渐增多,其治疗耗费了大量资源。UroLift® 系统是一项已获批准的技术,用于治疗继发性良性前列腺增生症(BPH)引起的下尿路症状(LUTS),并可用于实施前列腺尿道提升术(PUL)。西班牙多位具有前列腺尿道上提术经验的泌尿科专家编写了这份共识文件。本文件由西班牙泌尿外科协会批准,其信息以最新研究成果为基础。本文件的主要目的是向所有治疗 LUTS/BPH 患者的专业人员传播共识建议。初级保健医生和泌尿科医生都可以将 PUL 作为一种有效的微创治疗方法进行评估和提供。
{"title":"Clinical application of the UroLift® prostatic urethral lift in Spain: consensus on the treatment of lower urinary tract symptoms associated with urinary flow obstruction and secondary to benign prostatic hyperplasia (BPH)","authors":"M. Fernández Arjona ,&nbsp;L. López Martín ,&nbsp;L.M. Herranz Fernández ,&nbsp;B. Sinues Ojas ,&nbsp;J.M. Campá Bortoló ,&nbsp;J. Extramiana Cameno ,&nbsp;E. López Alcina ,&nbsp;I. Povo Martín ,&nbsp;A. Budía Alba ,&nbsp;G. Ordaz Jurado ,&nbsp;J.M. Osca García ,&nbsp;M. Perán Teruel ,&nbsp;V. Gimeno Argente ,&nbsp;A. Navarro Beltrán ,&nbsp;J. Benejam Gual ,&nbsp;Y.E. Hernández Martínez ,&nbsp;C. González Enguita","doi":"10.1016/j.acuroe.2024.09.004","DOIUrl":"10.1016/j.acuroe.2024.09.004","url":null,"abstract":"<div><div>Benign prostatic hyperplasia (BPH) is an increasingly common pathology in the adult male. BPH increases after the age of 40–45 years, and its management consumes an enormous amount of resources. The UroLift® System is an approved technology designed to treat lower urinary tract symptoms (LUTS) secondary to BPH and is used to perform the prostatic urethral lift (PUL) procedure. Various urology specialists in Spain with experience in PUL have prepared this consensus document. Endorsed by the Spanish Urology Association, its information is based on the most recent findings. The main objective of this document is to disseminate the consensus recommendations among all professionals treating patients with LUTS/BPH. Both primary care physicians and urologists can assess and offer PUL as an effective, minimally invasive treatment.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"48 10","pages":"Pages 732-738"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between varicocele and hypogonadism, or erectile dysfunction: A systematic review and meta-analysis 精索静脉曲张与性腺功能减退或勃起功能障碍之间的关系:系统回顾和荟萃分析。
Pub Date : 2024-12-01 DOI: 10.1016/j.acuroe.2024.06.006
S.J. Gonzalez-Daza , A.M. Díaz-Hung , H.A. García-Perdomo

Objective

To assess the association between varicocele and hypogonadism, or erectile dysfunction.

Methods

We searched MEDLINE, EMBASE, LILACS, CENTRAL, and other sources. We included cohort, case-control, and cross-sectional studies. The primary outcome was the association between varicocele and hypogonadism, or erectile dysfunction, and the secondary outcome included semen analysis. We assessed the risk of bias with the Newcastle-Ottawa Scale. We performed statistical analysis in Review Manager 5.3 and reported information about the Odds Ratio (OR) with a 95% confidence interval. We produced a forest plot for the primary outcome.

Results

We included ten studies in qualitative analysis and six studies in quantitative analysis. Most of the cross-sectional studies showed a low risk of bias, not so for the two case-control studies, which represented a high risk of bias. Most of the reports described a correlation between having varicocele and presenting low testosterone levels: the meta-analysis showed that there is a significant association between varicocele and hypogonadism (OR 3.27 95% CI 1.23 to 8.68). Regarding varicocele and erectile, only one study showed a significant difference in erectile function in comparison to varicocele patients and men without varicocele.

Conclusion

There is an association between varicocele presence and hypogonadism, although more studies are needed. Besides, not much is reported about an association between varicocele and erectile dysfunction, but impairment can occur through hormone disturbances.
目的:评估精索静脉曲张与性腺功能减退或勃起功能障碍之间的关系:评估精索静脉曲张与性腺功能减退或勃起功能障碍之间的关系:我们检索了 MEDLINE、EMBASE、LILACS、CENTRAL 和其他资料来源。我们纳入了队列研究、病例对照研究和横断面研究。主要结果是精索静脉曲张与性腺功能减退或勃起功能障碍之间的关系,次要结果包括精液分析。我们使用纽卡斯尔-渥太华量表评估了偏倚风险。我们在Review Manager 5.3中进行了统计分析,并报告了带有95%置信区间的比值比(OR)信息。我们为主要结果绘制了森林图:我们在定性分析中纳入了 10 项研究,在定量分析中纳入了 6 项研究。大多数横断面研究的偏倚风险较低,而两项病例对照研究的偏倚风险较高。大多数报告都描述了精索静脉曲张与睾酮水平低之间的相关性:荟萃分析表明,精索静脉曲张与性腺功能减退之间存在显著关联(OR 3.27 95%CI 1.23 至 8.68)。关于精索静脉曲张和勃起功能,只有一项研究显示,精索静脉曲张患者和无精索静脉曲张的男性在勃起功能方面存在显著差异:结论:精索静脉曲张与性腺功能减退之间存在关联,但还需要更多的研究。此外,关于精索静脉曲张与勃起功能障碍之间关系的报道并不多,但激素紊乱可能会导致勃起功能障碍。
{"title":"Association between varicocele and hypogonadism, or erectile dysfunction: A systematic review and meta-analysis","authors":"S.J. Gonzalez-Daza ,&nbsp;A.M. Díaz-Hung ,&nbsp;H.A. García-Perdomo","doi":"10.1016/j.acuroe.2024.06.006","DOIUrl":"10.1016/j.acuroe.2024.06.006","url":null,"abstract":"<div><h3>Objective</h3><div><span>To assess the association between varicocele and </span>hypogonadism<span>, or erectile dysfunction.</span></div></div><div><h3>Methods</h3><div><span><span>We searched MEDLINE, EMBASE, LILACS, CENTRAL, and other sources. We included cohort, case-control, and cross-sectional studies. The primary outcome was the association between varicocele and </span>hypogonadism<span>, or erectile dysfunction, and the secondary outcome included </span></span>semen analysis. We assessed the risk of bias with the Newcastle-Ottawa Scale. We performed statistical analysis in Review Manager 5.3 and reported information about the Odds Ratio (OR) with a 95% confidence interval. We produced a forest plot for the primary outcome.</div></div><div><h3>Results</h3><div>We included ten studies in qualitative analysis and six studies in quantitative analysis. Most of the cross-sectional studies showed a low risk of bias, not so for the two case-control studies, which represented a high risk of bias. Most of the reports described a correlation between having varicocele and presenting low testosterone levels: the meta-analysis showed that there is a significant association between varicocele and hypogonadism (OR 3.27 95% CI 1.23 to 8.68). Regarding varicocele and erectile, only one study showed a significant difference in erectile function in comparison to varicocele patients and men without varicocele.</div></div><div><h3>Conclusion</h3><div>There is an association between varicocele presence and hypogonadism, although more studies are needed. Besides, not much is reported about an association between varicocele and erectile dysfunction, but impairment can occur through hormone disturbances.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"48 10","pages":"Pages 751-759"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141500112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing triple therapy in patients with metastatic hormone-sensitive prostate cancer 优化对激素敏感的转移性前列腺癌患者的三联疗法。
Pub Date : 2024-12-01 DOI: 10.1016/j.acuroe.2024.10.005
A. Borque-Fernando , D.A. Pérez-Fentes , M. Rodrigo-Aliaga , J. Puente-Vázquez , A. Gómez-Iturriaga , M. Unda , M.A. Calleja-Hernández , J.M. Cózar-Olmo , J.L. Álvarez-Ossorio
Triple therapy with docetaxel, androgen deprivation therapy (ADT) and androgen receptor pathway inhibitors (ARPIs) has demonstrated survival benefits in patients with metastatic hormone-sensitive prostate cancer (mHSPC), especially in those with high-risk disease. However, once the use of ADT and docetaxel is established, guidelines do not clearly specify which ARPI is most appropriate. In this work, a literature review to identify phase III clinical trials, systematic reviews, meta-analyses, and clinical practice guidelines on triple therapy in mHSPC was carried out. Evidence and recommendations were qualitatively reviewed to provide guidelines on the most suitable ARPI based on patient risk, disease volume, and nature of metastases (synchronous or metachronous). This review aims to update the previously published consensus on the optimal pharmacological treatment for mHSPC and to expose the opinions of hospital pharmacy, urology and medical and radiation oncology experts.
多西他赛、雄激素剥夺疗法(ADT)和雄激素受体通路抑制剂(ARPI)三联疗法已证明对转移性激素敏感性前列腺癌(mHSPC)患者,尤其是高危患者的生存有好处。然而,一旦确定使用 ADT 和多西他赛,指南并未明确规定哪种 ARPI 最为合适。在这项工作中,我们进行了一项文献综述,以确定有关 mHSPC 三联疗法的 III 期临床试验、系统综述、荟萃分析和临床实践指南。对证据和建议进行了定性审查,以根据患者风险、疾病体积和转移性质(同步或同步)提供最合适的 ARPI 指南。本综述旨在更新之前发表的关于 mHSPC 最佳药物治疗的共识,并阐述医院药剂学、泌尿科、肿瘤内科和放射科专家的意见。
{"title":"Optimizing triple therapy in patients with metastatic hormone-sensitive prostate cancer","authors":"A. Borque-Fernando ,&nbsp;D.A. Pérez-Fentes ,&nbsp;M. Rodrigo-Aliaga ,&nbsp;J. Puente-Vázquez ,&nbsp;A. Gómez-Iturriaga ,&nbsp;M. Unda ,&nbsp;M.A. Calleja-Hernández ,&nbsp;J.M. Cózar-Olmo ,&nbsp;J.L. Álvarez-Ossorio","doi":"10.1016/j.acuroe.2024.10.005","DOIUrl":"10.1016/j.acuroe.2024.10.005","url":null,"abstract":"<div><div>Triple therapy with docetaxel, androgen deprivation therapy (ADT) and androgen receptor pathway inhibitors (ARPIs) has demonstrated survival benefits in patients with metastatic hormone-sensitive prostate cancer (mHSPC), especially in those with high-risk disease. However, once the use of ADT and docetaxel is established, guidelines do not clearly specify which ARPI is most appropriate. In this work, a literature review to identify phase III clinical trials, systematic reviews, meta-analyses, and clinical practice guidelines on triple therapy in mHSPC was carried out. Evidence and recommendations were qualitatively reviewed to provide guidelines on the most suitable ARPI based on patient risk, disease volume, and nature of metastases (synchronous or metachronous). This review aims to update the previously published consensus on the optimal pharmacological treatment for mHSPC and to expose the opinions of hospital pharmacy, urology and medical and radiation oncology experts.</div></div>","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"48 10","pages":"Pages 703-717"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards population-based screening for prostate cancer in Spain 在西班牙开展基于人口的前列腺癌筛查。
Pub Date : 2024-12-01 DOI: 10.1016/j.acuroe.2024.10.002
J. Morote Robles
{"title":"Towards population-based screening for prostate cancer in Spain","authors":"J. Morote Robles","doi":"10.1016/j.acuroe.2024.10.002","DOIUrl":"10.1016/j.acuroe.2024.10.002","url":null,"abstract":"","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"48 10","pages":"Pages 685-687"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The leaky pipeline and gender gaps in urology 泌尿外科的漏管和性别差距。
Pub Date : 2024-12-01 DOI: 10.1016/j.acuroe.2024.05.016
A. Medina Gamero
{"title":"The leaky pipeline and gender gaps in urology","authors":"A. Medina Gamero","doi":"10.1016/j.acuroe.2024.05.016","DOIUrl":"10.1016/j.acuroe.2024.05.016","url":null,"abstract":"","PeriodicalId":94291,"journal":{"name":"Actas urologicas espanolas","volume":"48 10","pages":"Page 760"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Actas urologicas espanolas
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1