{"title":"局部缓释药物治疗牙周炎和合并症糖尿病的疗效：系统回顾和荟萃分析","authors":"Jingru Zhuang (庄静茹) , Ying Ren (任颖) , Minmin Chen (陈敏敏) , Minghui Yue (岳明辉) , Changyong Yuan (袁长永) , Rongquan Duan (段荣泉)","doi":"10.1016/j.isci.2025.112182","DOIUrl":null,"url":null,"abstract":"<div><div>Our meta-analysis aimed to evaluate the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes. PubMed, Cochrane Library, Embase, and Web of Science were comprehensively searched until 4 December 2024, and 10 randomized controlled trials (RCTs) were included. The results indicated that, compared to the control group, localized sustained-release drugs significantly reduced probing depth (PD) (SMD = −0.77, 95% confidence interval [CI] (−1.37, −0.16)) but did not reduce clinical attachment loss (CAL) (SMD = −0.18, 95% CI (−0.60, 0.23)), sites with glycated hemoglobin (HbA1c) (SMD = 0.03, 95% CI (−0.38, 0.43)), plaque index (SMD = −0.37, 95% CI (−0.80, 0.06)), sites with bleeding on probing (BOP) (SMD = −0.26, 95% CI (−0.68, 0.16)), and gingival index (SMD = 0.07, 95% CI (−0.30, 0.44)). Subgroup analysis by different drugs elicited that, compared to the control treatment, chlorhexidine was effective in reducing BOP% (SMD = −0.55, 95% CI (−0.90, −0.19)). Our meta-analysis finds that the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes is limited.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112182"},"PeriodicalIF":4.1000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes: A systematic review and meta-analysis\",\"authors\":\"Jingru Zhuang (庄静茹) , Ying Ren (任颖) , Minmin Chen (陈敏敏) , Minghui Yue (岳明辉) , Changyong Yuan (袁长永) , Rongquan Duan (段荣泉)\",\"doi\":\"10.1016/j.isci.2025.112182\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Our meta-analysis aimed to evaluate the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes. PubMed, Cochrane Library, Embase, and Web of Science were comprehensively searched until 4 December 2024, and 10 randomized controlled trials (RCTs) were included. The results indicated that, compared to the control group, localized sustained-release drugs significantly reduced probing depth (PD) (SMD = −0.77, 95% confidence interval [CI] (−1.37, −0.16)) but did not reduce clinical attachment loss (CAL) (SMD = −0.18, 95% CI (−0.60, 0.23)), sites with glycated hemoglobin (HbA1c) (SMD = 0.03, 95% CI (−0.38, 0.43)), plaque index (SMD = −0.37, 95% CI (−0.80, 0.06)), sites with bleeding on probing (BOP) (SMD = −0.26, 95% CI (−0.68, 0.16)), and gingival index (SMD = 0.07, 95% CI (−0.30, 0.44)). Subgroup analysis by different drugs elicited that, compared to the control treatment, chlorhexidine was effective in reducing BOP% (SMD = −0.55, 95% CI (−0.90, −0.19)). Our meta-analysis finds that the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes is limited.</div></div>\",\"PeriodicalId\":342,\"journal\":{\"name\":\"iScience\",\"volume\":\"28 4\",\"pages\":\"Article 112182\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2025-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"iScience\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2589004225004432\",\"RegionNum\":2,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"iScience","FirstCategoryId":"103","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589004225004432","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes: A systematic review and meta-analysis
Our meta-analysis aimed to evaluate the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes. PubMed, Cochrane Library, Embase, and Web of Science were comprehensively searched until 4 December 2024, and 10 randomized controlled trials (RCTs) were included. The results indicated that, compared to the control group, localized sustained-release drugs significantly reduced probing depth (PD) (SMD = −0.77, 95% confidence interval [CI] (−1.37, −0.16)) but did not reduce clinical attachment loss (CAL) (SMD = −0.18, 95% CI (−0.60, 0.23)), sites with glycated hemoglobin (HbA1c) (SMD = 0.03, 95% CI (−0.38, 0.43)), plaque index (SMD = −0.37, 95% CI (−0.80, 0.06)), sites with bleeding on probing (BOP) (SMD = −0.26, 95% CI (−0.68, 0.16)), and gingival index (SMD = 0.07, 95% CI (−0.30, 0.44)). Subgroup analysis by different drugs elicited that, compared to the control treatment, chlorhexidine was effective in reducing BOP% (SMD = −0.55, 95% CI (−0.90, −0.19)). Our meta-analysis finds that the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes is limited.
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