GPX4甲基化抑制铁下垂

IF 19.1 1区生物学 Q1 CELL BIOLOGY Nature Cell Biology Pub Date : 2025-03-21 DOI:10.1038/s41556-025-01640-x

Graeme I. Lancaster, Andrew J. Murphy

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引用次数: 0

摘要

铁下垂是一种细胞死亡的形式，发生在许多病理条件下，是癌症治疗的目标。GPX4酶是细胞防止铁下垂的主要手段。现在的一项研究表明，GPX4的甲基化促进了它的稳定，防止GPX4甲基化可以改善癌症治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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GPX4 methylation puts a brake on ferroptosis

Ferroptosis is a form of cell death that occurs in many pathological conditions and is a target for cancer therapy. The enzyme GPX4 is the primary means by which cells guard against ferroptosis. A study now demonstrates that methylation of GPX4 promotes its stabilization, and that preventing GPX4 methylation improves cancer therapy.

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology