{"title":"基于核壳结构的智能水凝胶伤口敷料，内源性和外源性双粘附动态响应促进伤口愈合","authors":"Shuangying Li, Ren Li, Xiuwen Zhang, Yueyuan Zhu, Dong Wang, Wenpeng Cui, Hechen Chai, Yushun Hou, Shaoxiang Li","doi":"10.1002/adfm.202500329","DOIUrl":null,"url":null,"abstract":"<p>Herein, MIL-88b-NH<sub>2</sub> nanocage is designed with adenine inside the cage and tannins as gating outside the cage. Based on this core-shell structure, polyvinyl alcohol/carboxymethyl chitosan/MIL/adenine/tannic acid (PCMAT) hydrogels are able to respond endogenously and exogenously at different stages of wound healing. The engineered hydrogel is designed to have tunable adhesion and intelligence. The optimal PCMAT-0.3 hydrogel reduced the pore size to ≈13.5 µm under endogenous response conditions, and the antimicrobial performance reached more than 80% within 6 h. Tensile strength and strain at break are reduced by 8.47% and 60.52% respectively under exogenous response conditions. Evaluation of the healing effect on mouse back wound tissue shows that the wound healing rate is significantly better than the control group without nanocage incorporation on day 14. It provides an idea for the development of smart response hydrogel wound dressing that integrates multifunctionality.</p>","PeriodicalId":112,"journal":{"name":"Advanced Functional Materials","volume":"35 34","pages":""},"PeriodicalIF":19.9000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Core-Shell Structure-Based Smart Hydrogel Wound Dressing with Endogenous and Exogenous Dual Adhesion Dynamic Response to Promote Wound Healing\",\"authors\":\"Shuangying Li, Ren Li, Xiuwen Zhang, Yueyuan Zhu, Dong Wang, Wenpeng Cui, Hechen Chai, Yushun Hou, Shaoxiang Li\",\"doi\":\"10.1002/adfm.202500329\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Herein, MIL-88b-NH<sub>2</sub> nanocage is designed with adenine inside the cage and tannins as gating outside the cage. Based on this core-shell structure, polyvinyl alcohol/carboxymethyl chitosan/MIL/adenine/tannic acid (PCMAT) hydrogels are able to respond endogenously and exogenously at different stages of wound healing. The engineered hydrogel is designed to have tunable adhesion and intelligence. The optimal PCMAT-0.3 hydrogel reduced the pore size to ≈13.5 µm under endogenous response conditions, and the antimicrobial performance reached more than 80% within 6 h. Tensile strength and strain at break are reduced by 8.47% and 60.52% respectively under exogenous response conditions. Evaluation of the healing effect on mouse back wound tissue shows that the wound healing rate is significantly better than the control group without nanocage incorporation on day 14. It provides an idea for the development of smart response hydrogel wound dressing that integrates multifunctionality.</p>\",\"PeriodicalId\":112,\"journal\":{\"name\":\"Advanced Functional Materials\",\"volume\":\"35 34\",\"pages\":\"\"},\"PeriodicalIF\":19.9000,\"publicationDate\":\"2025-03-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Functional Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.202500329\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Functional Materials","FirstCategoryId":"88","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.202500329","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Core-Shell Structure-Based Smart Hydrogel Wound Dressing with Endogenous and Exogenous Dual Adhesion Dynamic Response to Promote Wound Healing
Herein, MIL-88b-NH2 nanocage is designed with adenine inside the cage and tannins as gating outside the cage. Based on this core-shell structure, polyvinyl alcohol/carboxymethyl chitosan/MIL/adenine/tannic acid (PCMAT) hydrogels are able to respond endogenously and exogenously at different stages of wound healing. The engineered hydrogel is designed to have tunable adhesion and intelligence. The optimal PCMAT-0.3 hydrogel reduced the pore size to ≈13.5 µm under endogenous response conditions, and the antimicrobial performance reached more than 80% within 6 h. Tensile strength and strain at break are reduced by 8.47% and 60.52% respectively under exogenous response conditions. Evaluation of the healing effect on mouse back wound tissue shows that the wound healing rate is significantly better than the control group without nanocage incorporation on day 14. It provides an idea for the development of smart response hydrogel wound dressing that integrates multifunctionality.
期刊介绍：
Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week.
Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
