3,5-二取代- 1h -吡唑：由n -酰基苯并三唑、炔和肼在离子液体中序贯合成

IF 2.5 4区化学 Q2 Engineering Chemical Papers Pub Date : 2025-01-06 DOI:10.1007/s11696-024-03880-x

Khalid Widyan

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引用次数: 0

摘要

采用n -酰基苯并三唑、末端炔和联氨，建立了一种不含铜和钯的序贯合成3,5-二取代1h -吡唑的新工艺。在氯化锌催化下，n -酰基苯并三唑与1-丁基-3-甲基咪唑四氟硼酸盐中的末端炔反应生成α，β-不饱和炔酮。然后这些中间体通过与联氨的原位反应转化为吡唑。此外，离子液体可以回收再利用，而不会显著降低效率。

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3,5-Disubstituted-1H-pyrazoles: sequential syntheses from N-acylbenzotriazoles, alkynes, and hydrazine in ionic liquid

A new procedure that is free of copper and palladium has been developed for the sequential synthesis of 3,5-disubstituted-1H-pyrazoles using various N-acylbenzotriazoles, terminal alkynes, and hydrazine. In this process, N-acylbenzotriazoles react with terminal alkynes in 1-butyl-3-methyl-imidazolium tetrafluoroborate, catalyzed by zinc chloride, to produce α,β-unsaturated alkynones. These intermediates are then converted into pyrazoles through an in-situ reaction with hydrazine. Additionally, the ionic liquid can be recovered and reused without significant loss of efficiency.

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来源期刊

Chemical Papers Chemical Engineering-General Chemical Engineering

CiteScore

3.30

自引率

4.50%

发文量

590

期刊介绍： Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.