铜催化 2-氨基吡啶与芳基硼酸通过 C-N 键形成苯并[4,5]咪唑并[1,2-a]吡啶衍生物的合成方法

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Research on Chemical Intermediates Pub Date : 2025-02-20 DOI:10.1007/s11164-025-05532-5

Xiao-Tang Li, Chuan-Jie Han, Zhan-Hui Zhang

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引用次数: 0

摘要

在 4-OH TEMPO 作为氧化剂的条件下，在醋酸铜 (II) 催化剂存在下，通过氨基吡啶和芳基硼酸的偶联反应，成功构建了一种创新的高效催化体系，并实现了苯并[4,5]咪唑并[1,2-a]吡啶的精确合成。该方法具有收率高、反应时间短、操作简单和反应条件温和等优点。

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A copper-catalyzed synthesis of benzo[4,5]imidazo[1,2-a]pyridine derivatives via C–N bond formation of 2-aminopyridines with arylboronic acids

An innovative and efficient catalytic system was successfully constructed, and the accurate synthesis of benzo[4,5]imidazo[1,2-a]pyridines was realized through the coupling reaction of aminopyridine and arylboronic acid in the presence of copper (II) acetate catalyst with 4-OH TEMPO as oxidant. The present methodology offers several advantages such as high yields, shorter reaction times, easy work-up process, and mild reaction conditions.

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来源期刊

Research on Chemical Intermediates 化学-化学综合

CiteScore

5.70

自引率

18.20%

发文量

229

审稿时长

2.6 months

期刊介绍： Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.