病例报告：视神经炎与原发性抗pla2r阳性膜性肾病共存。

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY BMC Neurology Pub Date : 2025-03-22 DOI:10.1186/s12883-025-04076-w

Xi Wang, Yuping Zeng, Yuliang Zhao, Boyi Li, Jing Yang

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摘要

背景：视神经炎（ON）是一种以急性视力丧失为特征的炎性视神经病变。原发性抗pla2r阳性膜性肾病是一种自身免疫性疾病，已报道与神经系统疾病有关。然而，ON和原发性膜性肾病（PMN）的共同发生尚未见报道。病例介绍：一名57岁男性，表现为急性双侧视力丧失。实验室检查显示蛋白尿、低白蛋白血症、高脂血症和抗磷脂酶A2受体抗体（PLA2RAb）水平显著升高。眼眶MRI显示双视神经后段炎性改变。在使用皮质类固醇和免疫抑制剂治疗后，患者的视力和蛋白尿有了显著改善。结论：本病例提示多系统自身免疫损伤的早期识别和干预对改善患者预后至关重要。

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Case report: Coexistence of optic neuritis and primary anti-PLA2R-positive membranous nephropathy.

Background: Optic neuritis (ON) is an inflammatory optic neuropathy characterized by acute vision loss. Primary anti-PLA2R-positive membranous nephropathy, an autoimmune disease, has been reported to be related to neurological diseases. However, the co-occurrence of ON and primary membranous nephropathy (PMN) has not been reported.

Case presentation: A 57-year-old male presented with acute bilateral vision loss. Laboratory tests indicated proteinuria, hypoalbuminemia, hyperlipidemia, and a significantly increased level of anti-phospholipase A2 receptor antibody (PLA2RAb). Orbital MRI revealed inflammatory changes in the posterior segments of both optic nerves. Following treatments with corticosteroids and immunosuppressants, there was a significant improvement in the patient's vision and proteinuria.

Conclusion: This case suggests that early identification and intervention for multisystem autoimmune damages are crucial for improving patient prognosis.

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来源期刊

BMC Neurology 医学-临床神经学

CiteScore

4.20

自引率

0.00%

发文量

428

审稿时长

3-8 weeks

期刊介绍： BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.