{"title":"下颌颌后缩候选基因的研究进展：系统综述","authors":"Li Yang , Weiping Yang , Yining Shen , Yu Zhou","doi":"10.1016/j.archoralbio.2025.106234","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>This research aims to dissect the polygenic nature of non-syndromic mandibular retrognathism (MR) and to better understand the genetic underpinnings of MR, with a particular focus on the role of ethnic diversity in influencing genetic predispositions.</div></div><div><h3>Methods</h3><div>A comprehensive systematic review was conducted on MR. Electronic databases such as PubMed and Google Scholar were employed, utilizing terms like 'mandibular', 'retrognathism', 'gene', and 'genetic'. This study strictly adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework.</div></div><div><h3>Results</h3><div>Ten genetic studies were identified that satisfied the eligibility criteria, involving 1010 participants. Variations in candidate genes were reported across different populations, including myosin 1 H (<em>MYO1H</em>), matrilin 1 (<em>MATN1</em>), a disintegrin and metalloproteinase with thrombospondin motifs 9 (<em>ADAMTS9</em>), bone morphogenetic protein 2 (<em>BMP2</em>), parathyroid hormone (<em>PTH</em>), the vitamin-D related genes: vitamin D receptor (<em>VDR</em>), cytochrome P450 family 24 subfamily A member 1 (<em>CYP24A1</em>), and cytochrome P450 family 27 subfamily B member 1 (<em>CYP27B1</em>), collagen type II alpha 1 chain (<em>COL2A1</em>), transforming growth factor-β (<em>TGF-β</em>), <em>TGF</em>-β receptor 2 (<em>TGFBR2</em>), epidermal growth factor (<em>EGF</em>), and EGF receptor gene (<em>EGFR</em>).</div></div><div><h3>Conclusion</h3><div>These findings shed light on the role of genetic factors in MR. Future studies should adopt a multicentric approach to expand sample sizes and enhance the analysis of genetic variants associated with MR.</div></div>","PeriodicalId":8288,"journal":{"name":"Archives of oral biology","volume":"174 ","pages":"Article 106234"},"PeriodicalIF":2.1000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advance in candidate genes in mandibular retrognathism: A systematic review\",\"authors\":\"Li Yang , Weiping Yang , Yining Shen , Yu Zhou\",\"doi\":\"10.1016/j.archoralbio.2025.106234\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>This research aims to dissect the polygenic nature of non-syndromic mandibular retrognathism (MR) and to better understand the genetic underpinnings of MR, with a particular focus on the role of ethnic diversity in influencing genetic predispositions.</div></div><div><h3>Methods</h3><div>A comprehensive systematic review was conducted on MR. Electronic databases such as PubMed and Google Scholar were employed, utilizing terms like 'mandibular', 'retrognathism', 'gene', and 'genetic'. This study strictly adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework.</div></div><div><h3>Results</h3><div>Ten genetic studies were identified that satisfied the eligibility criteria, involving 1010 participants. Variations in candidate genes were reported across different populations, including myosin 1 H (<em>MYO1H</em>), matrilin 1 (<em>MATN1</em>), a disintegrin and metalloproteinase with thrombospondin motifs 9 (<em>ADAMTS9</em>), bone morphogenetic protein 2 (<em>BMP2</em>), parathyroid hormone (<em>PTH</em>), the vitamin-D related genes: vitamin D receptor (<em>VDR</em>), cytochrome P450 family 24 subfamily A member 1 (<em>CYP24A1</em>), and cytochrome P450 family 27 subfamily B member 1 (<em>CYP27B1</em>), collagen type II alpha 1 chain (<em>COL2A1</em>), transforming growth factor-β (<em>TGF-β</em>), <em>TGF</em>-β receptor 2 (<em>TGFBR2</em>), epidermal growth factor (<em>EGF</em>), and EGF receptor gene (<em>EGFR</em>).</div></div><div><h3>Conclusion</h3><div>These findings shed light on the role of genetic factors in MR. Future studies should adopt a multicentric approach to expand sample sizes and enhance the analysis of genetic variants associated with MR.</div></div>\",\"PeriodicalId\":8288,\"journal\":{\"name\":\"Archives of oral biology\",\"volume\":\"174 \",\"pages\":\"Article 106234\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-03-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of oral biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0003996925000627\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of oral biology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0003996925000627","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Advance in candidate genes in mandibular retrognathism: A systematic review
Objective
This research aims to dissect the polygenic nature of non-syndromic mandibular retrognathism (MR) and to better understand the genetic underpinnings of MR, with a particular focus on the role of ethnic diversity in influencing genetic predispositions.
Methods
A comprehensive systematic review was conducted on MR. Electronic databases such as PubMed and Google Scholar were employed, utilizing terms like 'mandibular', 'retrognathism', 'gene', and 'genetic'. This study strictly adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework.
Results
Ten genetic studies were identified that satisfied the eligibility criteria, involving 1010 participants. Variations in candidate genes were reported across different populations, including myosin 1 H (MYO1H), matrilin 1 (MATN1), a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9), bone morphogenetic protein 2 (BMP2), parathyroid hormone (PTH), the vitamin-D related genes: vitamin D receptor (VDR), cytochrome P450 family 24 subfamily A member 1 (CYP24A1), and cytochrome P450 family 27 subfamily B member 1 (CYP27B1), collagen type II alpha 1 chain (COL2A1), transforming growth factor-β (TGF-β), TGF-β receptor 2 (TGFBR2), epidermal growth factor (EGF), and EGF receptor gene (EGFR).
Conclusion
These findings shed light on the role of genetic factors in MR. Future studies should adopt a multicentric approach to expand sample sizes and enhance the analysis of genetic variants associated with MR.
期刊介绍：
Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including:
Cell and molecular biology
Molecular genetics
Immunology
Pathogenesis
Cellular microbiology
Embryology
Syndromology
Forensic dentistry
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