Yu-Qing Xie, Xin-Yue Zhang, Jun-Hui Zhang, Ping He, Sheng-He Yang, Yan Fu, Zhi-Yu Ni, Jian Su, Yu-Cheng Gu, Yi-Bing Wu
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引用次数: 0
摘要
来自Pentanema britannicum （L.）的花D.Gut.Larr。结果表明，从该化合物中分离得到3个新化合物，分别为britannitin A(1)、britannitin B(2)和britannitin C(3)，以及17个已知化合物。化合物1-3为甾烷倍半萜内酯，具有罕见的碳7和碳11 -C连接。分离化合物的结构测定是通过一系列光谱技术实现的，如一维和二维核磁共振分析。化合物5β-羟基asperilin （HA）能够改善CSDS诱导的小鼠抑郁样行为，提示其潜在的抗抑郁作用。
Novel eudesmanolides from the flowers of Pentanema britannicum (L.) D.Gut.Larr with antidepressant activities.
From the flowers of Pentanema britannicum (L.) D.Gut.Larr., three new eudesmanolides, britannitin A (1), britannitin B (2) and britannitin C (3), as well as 17 known compounds, were successfully extracted. Compounds 1-3 were eudesmane sesquiterpene lactones with a rare -C = C- linking carbons 7 and 11. Structural determination of the separated compounds was achieved through a range of spectroscopic techniques, such as 1D and 2D NMR analyses. Compound 5β-hydroxyasperilin (HA) demonstrated the ability to ameliorate depression-like behaviours in mice induced by CSDS, suggesting its potential antidepressant effect.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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