{"title":"观察镁对NMDA受体的多面作用。","authors":"Adam Fekete, Lu-Yang Wang","doi":"10.1016/j.neuron.2025.03.011","DOIUrl":null,"url":null,"abstract":"<p><p>NMDARs act as coincidence detectors for synaptic plasticity by activity-dependent relief of Mg<sup>2+</sup> pore block. In this issue of Neuron, Huang et al. solved the structure of NMDARs to enlighten the fascinating actions of Mg<sup>2+</sup> beyond its pore binding.<sup>1</sup>.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":"113 7","pages":"963-965"},"PeriodicalIF":15.0000,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Spotting multifaced actions of magnesium on NMDA receptors.\",\"authors\":\"Adam Fekete, Lu-Yang Wang\",\"doi\":\"10.1016/j.neuron.2025.03.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>NMDARs act as coincidence detectors for synaptic plasticity by activity-dependent relief of Mg<sup>2+</sup> pore block. In this issue of Neuron, Huang et al. solved the structure of NMDARs to enlighten the fascinating actions of Mg<sup>2+</sup> beyond its pore binding.<sup>1</sup>.</p>\",\"PeriodicalId\":19313,\"journal\":{\"name\":\"Neuron\",\"volume\":\"113 7\",\"pages\":\"963-965\"},\"PeriodicalIF\":15.0000,\"publicationDate\":\"2025-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuron\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.neuron.2025.03.011\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuron","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neuron.2025.03.011","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Spotting multifaced actions of magnesium on NMDA receptors.
NMDARs act as coincidence detectors for synaptic plasticity by activity-dependent relief of Mg2+ pore block. In this issue of Neuron, Huang et al. solved the structure of NMDARs to enlighten the fascinating actions of Mg2+ beyond its pore binding.1.
期刊介绍：
Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.
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