{"title":"6-杜鹃花的有机光催化三氟甲基化反应","authors":"Krishna Kanta Das and Alakananda Hajra","doi":"10.1039/D5RA00743G","DOIUrl":null,"url":null,"abstract":"<p >An efficient, cost-effective, and metal-free photocatalytic trifluoromethylation of 6-azauracils has been developed using Langlois reagent (CF<small><sub>3</sub></small>SO<small><sub>2</sub></small>Na) under ambient air. The present protocol, which utilizes an inexpensive CF<small><sub>3</sub></small> reagent and an organophotocatalyst, provides a convenient way to prepare trifluoromethylated azauracil derivatives with a variety of functional groups. The experimental results suggest a radical mechanistic pathway for this methodology.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 15","pages":" 11370-11376"},"PeriodicalIF":4.6000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra00743g?page=search","citationCount":"0","resultStr":"{\"title\":\"The organophotocatalytic trifluoromethylation of 6-azauracils†\",\"authors\":\"Krishna Kanta Das and Alakananda Hajra\",\"doi\":\"10.1039/D5RA00743G\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >An efficient, cost-effective, and metal-free photocatalytic trifluoromethylation of 6-azauracils has been developed using Langlois reagent (CF<small><sub>3</sub></small>SO<small><sub>2</sub></small>Na) under ambient air. The present protocol, which utilizes an inexpensive CF<small><sub>3</sub></small> reagent and an organophotocatalyst, provides a convenient way to prepare trifluoromethylated azauracil derivatives with a variety of functional groups. The experimental results suggest a radical mechanistic pathway for this methodology.</p>\",\"PeriodicalId\":102,\"journal\":{\"name\":\"RSC Advances\",\"volume\":\" 15\",\"pages\":\" 11370-11376\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-04-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra00743g?page=search\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"RSC Advances\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/ra/d5ra00743g\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"RSC Advances","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/ra/d5ra00743g","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
The organophotocatalytic trifluoromethylation of 6-azauracils†
An efficient, cost-effective, and metal-free photocatalytic trifluoromethylation of 6-azauracils has been developed using Langlois reagent (CF3SO2Na) under ambient air. The present protocol, which utilizes an inexpensive CF3 reagent and an organophotocatalyst, provides a convenient way to prepare trifluoromethylated azauracil derivatives with a variety of functional groups. The experimental results suggest a radical mechanistic pathway for this methodology.
期刊介绍：
An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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