Pan Zhou , Mengru Guo , Jiawei Li , Xu Li , Danyang Xie , Bo Qin , Yong Xia
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Remote radical alkynylation of unactivated C(sp3)–H bonds of ethynesulfonamides†
We report an efficient protocol for the construction of δ-alkynyl amides via 1,5-hydrogen atom transfer and alkynyl group transfer of ethynesulfonamides. The readily installed ethynesulfonamides serve as both an amidyl radical precursor and an alkyne source. This reaction features excellent site selectivity for tertiary, secondary, primary, and benzylic C(sp3)–H bonds.
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