Yuan-Zhan Han , Peng-Fei Song , Hai-Yang Zhao , Junbin Han , Xingang Zhang
{"title":"[18F]三氟化单氟烷基酯的放射性标记氟化合成[18]二氟甲基化烷烃","authors":"Yuan-Zhan Han , Peng-Fei Song , Hai-Yang Zhao , Junbin Han , Xingang Zhang","doi":"10.1039/d5cc00869g","DOIUrl":null,"url":null,"abstract":"<div><div>An efficient method for the synthesis of [<sup>18</sup>F]-difluoromethylated alkanes by the combination of [<sup>18</sup>F]radio-fluoride with monofluoroalkyl triflates has been developed. This method uses [<sup>18</sup>F]KF/K<sub>2.2.2</sub> as the fluorine source. It features synthetic simplicity without tedious precursor preparation, high RCC and RCY, good functional group tolerance, and is silver salt-free, providing potential for developing new PET agents.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"61 39","pages":"Pages 7113-7116"},"PeriodicalIF":4.2000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[18F]Radiolabeling fluorination of monofluoroalkyl triflates for the synthesis of [18F]difluoromethylated alkanes†\",\"authors\":\"Yuan-Zhan Han , Peng-Fei Song , Hai-Yang Zhao , Junbin Han , Xingang Zhang\",\"doi\":\"10.1039/d5cc00869g\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>An efficient method for the synthesis of [<sup>18</sup>F]-difluoromethylated alkanes by the combination of [<sup>18</sup>F]radio-fluoride with monofluoroalkyl triflates has been developed. This method uses [<sup>18</sup>F]KF/K<sub>2.2.2</sub> as the fluorine source. It features synthetic simplicity without tedious precursor preparation, high RCC and RCY, good functional group tolerance, and is silver salt-free, providing potential for developing new PET agents.</div></div>\",\"PeriodicalId\":67,\"journal\":{\"name\":\"Chemical Communications\",\"volume\":\"61 39\",\"pages\":\"Pages 7113-7116\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-04-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1359734525007566\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734525007566","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/11 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
[18F]Radiolabeling fluorination of monofluoroalkyl triflates for the synthesis of [18F]difluoromethylated alkanes†
An efficient method for the synthesis of [18F]-difluoromethylated alkanes by the combination of [18F]radio-fluoride with monofluoroalkyl triflates has been developed. This method uses [18F]KF/K2.2.2 as the fluorine source. It features synthetic simplicity without tedious precursor preparation, high RCC and RCY, good functional group tolerance, and is silver salt-free, providing potential for developing new PET agents.
期刊介绍：
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
