CRISPR- cas9和CRISPR干扰技术在自身免疫性疾病治疗中的作用

IF 8.3 1区医学 Q1 IMMUNOLOGY Autoimmunity reviews Pub Date : 2025-06-24 Epub Date: 2025-04-10 DOI:10.1016/j.autrev.2025.103816

Zahra Khademi , Negar Mottaghi-Dastjerdi , Hamed Morad , Amirhossein Sahebkar

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引用次数: 0

摘要

自身免疫性疾病可以被描述为针对自身抗原的不适当免疫反应，这在世界范围内引起了大量的医疗保健问题。免疫抑制或免疫调节是自身免疫性疾病的主要治疗方式。然而，这些模式损害了免疫系统抵抗感染的能力，从而易患机会性疾病。这篇综述探讨了自身免疫性疾病的现有治疗方法，强调了它们的局限性和挑战。此外，它还描述了CRISPR-Cas9技术作为解决这些挑战的新型治疗方法的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role of CRISPR-Cas9 and CRISPR interference technologies in the treatment of autoimmune diseases

Autoimmune disorders can be described as inappropriate immune responses directed against self-antigens, which account for substantial healthcare concerns around the world. Immunosuppression or immune modulation are the main therapeutic modalities for autoimmune disorders. These modalities, however, impair the ability of the immune system to fight against infections, thereby predisposing to opportunistic diseases. This review explores existing therapies for autoimmune disorders, highlighting their limitations and challenges. Additionally, it describes the potential of CRISPR-Cas9 technology as a novel therapeutic approach to address these challenges.

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.