Yu. E. Sabutski, S. M. Kovach, N. N. Balaneva, K. L. Borisova, E. A. Chingizova, E. S. Menchinskaya, A. L. Burylova, A. R. Chingizov, B. P. Mashnev, D. N. Pelageev
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引用次数: 0
摘要
合成了生物碱多卡品和多卡品C的类似物，它们是多卡品属海洋腹足类的代谢物。对它们的细胞毒性和抗菌活性进行了比较分析。结果表明，聚卡泊林 C 的含氯类似物对金黄色葡萄球菌和大肠杆菌具有很强的抗菌活性，优于庆大霉素。聚卡泊林 C 及其硫代类似物可强烈抑制所研究微生物的生物膜形成。
Antimicrobial and Cytotoxic Activity of Imidazole and Thiazole Analogs of Polycarpine and Polycarpaurine C
Analogs of the alkaloids polycarpine and polycarpaurine C, metabolites of marine ascidians of the genus Polycarpa, were synthesized. Their cytotoxic and antimicrobial activities were comparatively analyzed. A chloro-containing analog of polycarpaurine C was shown to exhibit high antibacterial activity against Staphylococcus aureus and Escherichia coli superior to that of gentamicin. Polycarpaurine C and its thioanalogs strongly inhibited biofilm formation by the studied microorganisms.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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