铜离子与双链DNA中5-氟尿嘧啶自然修饰碱基对的新型特异性结合

IF 3.3 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Dalton Transactions Pub Date : 2025-04-15 DOI:10.1039/D5DT00619H

Hidetaka Torigoe, Kei Hirabayashi, Saki Adachi and Jiro Kondo

{"title":"铜离子与双链DNA中5-氟尿嘧啶自然修饰碱基对的新型特异性结合","authors":"Hidetaka Torigoe, Kei Hirabayashi, Saki Adachi and Jiro Kondo","doi":"10.1039/D5DT00619H","DOIUrl":null,"url":null,"abstract":"Only mercury(II) and silver(I) ions are known to specifically bind to natural and naturally modified base pairs in duplex DNA to form metal-mediated base pairs. We found novel, specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil (FdU) in duplex DNA, forming C–Cu–FdU and FdU–Cu–C base pairs.","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":" 18","pages":" 7208-7213"},"PeriodicalIF":3.3000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/dt/d5dt00619h?page=search","citationCount":"0","resultStr":"{\"title\":\"Novel specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil in duplex DNA†\",\"authors\":\"Hidetaka Torigoe, Kei Hirabayashi, Saki Adachi and Jiro Kondo\",\"doi\":\"10.1039/D5DT00619H\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Only mercury(II) and silver(I) ions are known to specifically bind to natural and naturally modified base pairs in duplex DNA to form metal-mediated base pairs. We found novel, specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil (FdU) in duplex DNA, forming C–Cu–FdU and FdU–Cu–C base pairs.\",\"PeriodicalId\":71,\"journal\":{\"name\":\"Dalton Transactions\",\"volume\":\" 18\",\"pages\":\" 7208-7213\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.rsc.org/en/content/articlepdf/2025/dt/d5dt00619h?page=search\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dalton Transactions\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/dt/d5dt00619h\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dalton Transactions","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/dt/d5dt00619h","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}

引用次数: 0

摘要

只有汞（II）和银(I)离子特异性地与双链DNA中的天然和自然修饰的碱基对结合，形成金属介导的碱基对。我们发现铜离子与双链DNA中含有5-氟尿嘧啶（FdU）的自然修饰碱基对结合形成C-Cu-FdU和FdU - cu - c。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Novel specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil in duplex DNA†

Only mercury(II) and silver(I) ions are known to specifically bind to natural and naturally modified base pairs in duplex DNA to form metal-mediated base pairs. We found novel, specific binding of copper ions to naturally modified base pairs involving 5-fluorouracil (FdU) in duplex DNA, forming C–Cu–FdU and FdU–Cu–C base pairs.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Dalton Transactions 化学-无机化学与核化学

CiteScore

6.60

自引率

7.50%

发文量

1832

审稿时长

1.5 months

期刊介绍： Dalton Transactions is a journal for all areas of inorganic chemistry, which encompasses the organometallic, bioinorganic and materials chemistry of the elements, with applications including synthesis, catalysis, energy conversion/storage, electrical devices and medicine. Dalton Transactions welcomes high-quality, original submissions in all of these areas and more, where the advancement of knowledge in inorganic chemistry is significant.