大阪耐大环内酯肺炎支原体感染率再次上升

IF 2 Q2 RESPIRATORY SYSTEM Respiratory investigation Pub Date : 2025-07-01 Epub Date: 2025-04-22 DOI:10.1016/j.resinv.2025.04.009

Naoyuki Miyashita, Makoto Ogata, Naoki Fukuda, Akihisa Yamura, Tomoki Ito

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引用次数: 0

摘要

目的了解2018 - 2024年耐大环内酯肺炎支原体的流行情况及耐药机制。方法采用聚合酶链反应法对367例肺炎支原体感染患者进行分析。结果2018年51例患者中有9例（17.6%）发现耐药肺炎支原体，2019年63例患者中有13例（20.6%），2020年30例患者中有8例（26.7%），2021年3例患者中有1例，2022年3例患者中有1例，2023年6例患者中有3例，2024年211例患者中有127例（60.2%）。与2018-2020年相比，2024年耐大环内酯肺炎支原体患病率显著增加(p <；0.0001)。大多数耐药菌株在肺炎支原体23S rRNA结构域V基因区2063位发生A-to-G转变，这与对大环内酯类药物的高水平耐药有关。结论大阪府地区大环内酯类耐药肺炎支原体感染率再次上升。

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Macrolide-resistant Mycoplasma pneumoniae infection prevalence increases again in Osaka

Objectives

We investigated the prevalence rate and resistance mechanism of macrolide-resistant Mycoplasma pneumoniae strains between 2018 and 2024.

Methods

We analyzed 367 patients with M. pneumoniae infection by the polymerase chain reaction method.

Results

Macrolide-resistant M. pneumoniae was identified in nine of 51 patients (17.6 %) in 2018, 13 of 63 patients (20.6 %) in 2019, eight of 30 patients (26.7 %) in 2020, one of three patients in 2021, one of three patients in 2022, three of six patients in 2023, and 127 of 211 patients (60.2 %) in 2024. Prevalence of macrolide-resistant M. pneumoniae was significantly increased in 2024 compared to the years 2018–2020 (p < 0.0001). The majority of resistant strains had an A-to-G transition at position 2063 in the M. pneumoniae 23S rRNA domain V gene region, which is associated with high-level resistance to macrolides.