下唇鼻窦、锥形凸起、中位凹陷与唇裂类型的相关性

R. Ranta
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引用次数: 10

摘要

芬兰唇腭裂CL(P)和孤立性腭裂(CP)患者常染色体显性遗传Van der Woude综合征的发生率约为2.5%。在CP患者中,下唇锥形凸起(CE)的发生率为39%,在CL(P)患者中为0.8%。注意到鼻窦和CE的发病机制相似。使用以下分类来研究鼻窦与CE之间的关系:(1)鼻窦;双侧,单侧,非典型;(2) CE:双边、单边;(3)下唇正中凹陷(MD);(4)鼻窦与CE联合;(5)合并CE和MD。将77例鼻窦患者和156例CE和/或MD患者分为CL(P)、CP、Pierre Robin anomalad (PR)和非裂患者亚组。结果:鼻窦双侧52%,单侧34%,非典型14%;无伴鼻窦的CE均为双侧;在所有鼻窦患者中,77%的鼻窦与CE有关。与普通组的CE发生率(39%和0.8%)相比,CP(92%)和CL(P)(61%)鼻窦组CE的发生率高,表明这两种下唇疾病之间关系密切,但遗传病因的相似性尚不清楚。
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Correlations of sinus, conical elevation, median depression of the lower lip and types of oral clefts

The incidence of autosomal dominantly inherited Van der Woude's syndrome among Finnish patients with cleft lip and palate CL(P) and with isolated cleft palate (CP) is approximately 2.5%. The incidence of conical elevation of the lower lip (CE) is 39% in CP and 0.8% in CL(P) patients. A pathogenetic similarity of sinuses and CE's was noted. The following classification was used to study associations between sinuses and CE's: (1) sinus; bilateral, unilateral, atypical; (2) CE: bilateral, unilateral; (3) median depression of the lower lip (MD); (4) combined sinus and CE; (5) combined CE and MD. According to the classification developed, a group of 77 sinus patients and 156 CE and/or MD patients was classified in subgroups of CL(P), CP, Pierre Robin anomalad (PR) and non-cleft subjects. The findings were: the sinus was bilateral on 52%, unilateral in 34% and atypical in 14%; the CE without associated sinus was bilateral in all cases; the sinus was associated with CE in 77% of all sinus subjects. The highly increased incidence of the CE in the CP (92%) and in the CL(P) (61%) sinus groups compared to the incidences of CE in these groups in general (39% and 0.8%) shows a close relationship between these 2 disorders of the lower lip, but the similarity of the genetic etiology still remains unclear.

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