Jun Liu , Yangyang Xu , Xiangyun Lin , Nan Ma , Qiongqiong Zhu , Kunlin Yang , Xinfei Li , Chang Liu , Ninghan Feng , Yuxia Zhao , Xuesong Li , Wei Zhang
{"title":"聚赖氨酸毛刷表面引发聚合固定化硅胶导管长效抗菌涂层的研究","authors":"Jun Liu , Yangyang Xu , Xiangyun Lin , Nan Ma , Qiongqiong Zhu , Kunlin Yang , Xinfei Li , Chang Liu , Ninghan Feng , Yuxia Zhao , Xuesong Li , Wei Zhang","doi":"10.1016/j.colsurfb.2022.113015","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Bacterial colonization of indwelling catheter remains a major threat in healthcare units worldwide. Developing approaches to prevent catheter-associated infections (CAIs) is, therefore, in great demand. Herein, to endow </span>silicone<span> catheter with long-term antibacterial properties, antimicrobial poly-</span></span><span>L</span>-lysine (PLL) brush was developed on the surface of catheter <em>via</em><span> surface initiated ring open polymerization. Surface characterizations<span> confirmed the successful immobilization of PLL. The PLL-tethered catheter showed potent antibacterial activities against catheter-associated urinary tract infections (CAUTIs) related pathogens. Moreover, after immersing in simulated body fluid for 28 days or incubating at 60 °C for 65 days, the bactericidal properties of PLL-tethered catheter were still retained. Furthermore, the PLL-tethered catheter exhibited good anti-infection activity and biocompatibility </span></span><em>in vivo</em>. The PLL-tethered surfaces hold great potential in the development of antibacterial silicone catheter to combat CAIs in clinical applications.</p></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":null,"pages":null},"PeriodicalIF":5.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Immobilization of poly-L-lysine brush via surface initiated polymerization for the development of long-term antibacterial coating for silicone catheter\",\"authors\":\"Jun Liu , Yangyang Xu , Xiangyun Lin , Nan Ma , Qiongqiong Zhu , Kunlin Yang , Xinfei Li , Chang Liu , Ninghan Feng , Yuxia Zhao , Xuesong Li , Wei Zhang\",\"doi\":\"10.1016/j.colsurfb.2022.113015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>Bacterial colonization of indwelling catheter remains a major threat in healthcare units worldwide. Developing approaches to prevent catheter-associated infections (CAIs) is, therefore, in great demand. Herein, to endow </span>silicone<span> catheter with long-term antibacterial properties, antimicrobial poly-</span></span><span>L</span>-lysine (PLL) brush was developed on the surface of catheter <em>via</em><span> surface initiated ring open polymerization. Surface characterizations<span> confirmed the successful immobilization of PLL. The PLL-tethered catheter showed potent antibacterial activities against catheter-associated urinary tract infections (CAUTIs) related pathogens. Moreover, after immersing in simulated body fluid for 28 days or incubating at 60 °C for 65 days, the bactericidal properties of PLL-tethered catheter were still retained. Furthermore, the PLL-tethered catheter exhibited good anti-infection activity and biocompatibility </span></span><em>in vivo</em>. The PLL-tethered surfaces hold great potential in the development of antibacterial silicone catheter to combat CAIs in clinical applications.</p></div>\",\"PeriodicalId\":279,\"journal\":{\"name\":\"Colloids and Surfaces B: Biointerfaces\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Colloids and Surfaces B: Biointerfaces\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0927776522006993\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloids and Surfaces B: Biointerfaces","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0927776522006993","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOPHYSICS","Score":null,"Total":0}
Immobilization of poly-L-lysine brush via surface initiated polymerization for the development of long-term antibacterial coating for silicone catheter
Bacterial colonization of indwelling catheter remains a major threat in healthcare units worldwide. Developing approaches to prevent catheter-associated infections (CAIs) is, therefore, in great demand. Herein, to endow silicone catheter with long-term antibacterial properties, antimicrobial poly-L-lysine (PLL) brush was developed on the surface of catheter via surface initiated ring open polymerization. Surface characterizations confirmed the successful immobilization of PLL. The PLL-tethered catheter showed potent antibacterial activities against catheter-associated urinary tract infections (CAUTIs) related pathogens. Moreover, after immersing in simulated body fluid for 28 days or incubating at 60 °C for 65 days, the bactericidal properties of PLL-tethered catheter were still retained. Furthermore, the PLL-tethered catheter exhibited good anti-infection activity and biocompatibility in vivo. The PLL-tethered surfaces hold great potential in the development of antibacterial silicone catheter to combat CAIs in clinical applications.
期刊介绍:
Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields.
Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication.
The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.