氯佐菌素(NSC-178248)治疗晚期人类癌症的II期评价

Robert W. Talley , Michael K. Samson , Robert W. Brownlee , Ahmad M. Samhouri , Roberto J. Fraile , Laurence H. Baker
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引用次数: 10

摘要

氯代虫胺(CZT)是一种水溶性亚硝基脲,进行了II期评估,以确定其对多种人类转移性肿瘤的有效性和毒性。给药方案为90或120 mg/m2,每6周静脉注射一次。剂量的增加或减少取决于毒性。有152例患者可评估反应。唯一观察到显著缓解率的是非霍奇金淋巴瘤(5/11)和肉瘤(4/27)。在乳腺癌和肺燕麦细胞癌中观察到单一反应。在黑色素瘤、结直肠癌、肾癌、非燕麦细胞肺癌、胰腺、胃等癌中均未见应答。血液学毒性如预测的那样很小,但似乎是累积的。G.I.的主要毒性是恶心和呕吐——通常是可控的。偶有肝酶升高,6例出现氮血症。两者都是可逆的。罕见的皮肤和偶尔的中枢神经系统反应也可见。
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Phase II evaluation of chlorozotocin (NSC-178248) in advanced human cancer

A phase II evaluation of chlorozoticin (CZT), a water soluble nitrosourea, was undertaken to determine its effectiveness and toxicity in a variety of human metastatic neoplasms. The dosage regimen chosen was either 90 or 120 mg/m2 given by i.v. bolus every six weeks. Dosage escalation or de-escalation was dependent on toxicity. There have been 152 patients evaluable for response. The only significant response rates observed were in non-Hodgkin's lymphoma (5/11) and sarcoma (4/27). Single responses were observed in breast and oat cell carcinoma of lung. No responses were observed in melanoma, colorectal, kidney, non-oat cell lung, pancreas, stomach and other carcinomas. Hematological toxicity has been minimal as predicted, but does appear to be cumulative. The major G.I. toxicity has been nausea and vomiting—usually controllable. Occasional hepatic enzyme elevations were observed, and azotemia was observed in 6 patients. Both were reversible. Rare skin and occasional CNS reactions were also seen.

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