21三体患儿及其父母中性粒细胞碱性磷酸酶测定。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-09-01

J Grozdea, G Bourrouillou, J Verdier, P Colombies

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摘要

对70例21三体患儿父母(35对夫妇)及其35例21三体患儿与110例对照父母(55对夫妇)及其正常患儿的核型和中性粒细胞碱性磷酸酶(NAP)进行了比较研究。在21三体家族中，我们发现NAP显著增加:母亲P小于10-4;父亲P小于10-4;10-9岁以下儿童;患儿的NAP水平近似等于父母双方的NAP水平之和(P = 0.80;Sigma2 = 5%)。在一个21三体儿童的父母，核型异常存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Neutrophil alkaline phosphatase in children with trisomy 21 and their parents.

A comparative study of karyotypes and neutrophil alkaline phosphatase (NAP) was carried out for 70 parents (35 couples) of trisomy 21 children and their 35 trisomy 21 children and for 110 control parents (55 couples) and their normal children. In the trisomy 21 families we found a significant increase in NAP: mother P less than 10-4; father P less than 10-4; children P less than 10-9; the NAP level in affected child is approximately equal to the sum of the NAP levels of the two parents (P = 0.80; sigma2 = 5%). In one parent of a trisomy 21 child, a karyotype anomaly was present.

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Biomedicine / [publiee pour l'A.A.I.C.I.G.]

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