{"title":"高γ球蛋白血症性紫癜单克隆类风湿因子的分离。","authors":"J L Preud'homme, F Duarte, P Aucouturier","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Rheumatoid factors were isolated for immunochemical study by a simple procedure based on immunoadsorption after dissociation of immune complexes. A monoclonal IgA that was not detectable in the patient's unseparated serum was thus demonstrated in one case of hypergammaglobulinemic purpura whereas polyclonal anti-IgG antibodies were isolated in several patients with autoimmune diseases.</p>","PeriodicalId":77707,"journal":{"name":"Diagnostic immunology","volume":"2 4","pages":"219-23"},"PeriodicalIF":0.0000,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Isolation of monoclonal rheumatoid factors in hypergammaglobulinemic purpura.\",\"authors\":\"J L Preud'homme, F Duarte, P Aucouturier\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Rheumatoid factors were isolated for immunochemical study by a simple procedure based on immunoadsorption after dissociation of immune complexes. A monoclonal IgA that was not detectable in the patient's unseparated serum was thus demonstrated in one case of hypergammaglobulinemic purpura whereas polyclonal anti-IgG antibodies were isolated in several patients with autoimmune diseases.</p>\",\"PeriodicalId\":77707,\"journal\":{\"name\":\"Diagnostic immunology\",\"volume\":\"2 4\",\"pages\":\"219-23\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diagnostic immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic immunology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Isolation of monoclonal rheumatoid factors in hypergammaglobulinemic purpura.
Rheumatoid factors were isolated for immunochemical study by a simple procedure based on immunoadsorption after dissociation of immune complexes. A monoclonal IgA that was not detectable in the patient's unseparated serum was thus demonstrated in one case of hypergammaglobulinemic purpura whereas polyclonal anti-IgG antibodies were isolated in several patients with autoimmune diseases.
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