可手术实体瘤的术前化疗

Anaxagoras N. Papaioannou
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引用次数: 21

摘要

越来越多的证据表明,大多数常见的人类实体瘤在临床检测时有潜在的转移。进一步的证据表明,当原发病灶被切除时,其微转移可能由于免疫抑制和其他促瘤因子在围手术期的作用而增强。在这种有利的环境下,在手术操作期间被迫进入循环的细胞也可能促进新转移的发展。建议上述事件在治疗结果中是重要的,并且如果治疗首先针对这些肿瘤的系统组成部分,它们可能在一定程度上得到预防;切除主要病灶可以在以后进行。实验和临床研究的结果以及许多理论考虑都支持这种方法在可手术实体肿瘤治疗中的潜在价值。
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Preoperative chemotherapy for operable solid tumours

Accumulating evidence suggests that most common solid tumours in man have latent metastases when clinically detected. Further evidence indicates that when the primary focus is resected, its micrometastases may become enhanced as a result of immunosuppression and other tumour-promoting factors at work in the perioperative period. In this favourable setting, the development of new metastases may also be facilitated from cells forced into the circulation during operative manipulations. It is suggested that the above events are important in the treatment outcome and that they may be prevented to some extent if treatment is first directed to the systemic component of these tumours; resections of the primary focus can be more advantageously done later. Results from experimental and clinical studies as well as many theoretical considerations support the potential value of this approach in the management of operable solid tumours.

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