结直肠癌肠准备的适应症和技术。

M R Keighley, J R Lee, N S Ambrose
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摘要

一个令人满意的肠道准备是必要的充分的双重对比钡灌肠和结肠镜检查。在择期结肠手术中,有效的准备对于降低吻合口裂开和脓毒症的风险也很重要。通过饥饿、净化和灌肠的传统制备是耗时的,对患者来说是不愉快的,根据我们的经验,只有23%的患者的制备结果令人满意。如果只使用五天,基本饮食是无效的。鼻胃管全肠冲洗使患者在手术前只需住院一天,61%的患者获得满意的结果。对于狭窄性肿瘤,不建议全肠冲洗。用生理盐水冲洗会导致钠和水潴留,而使用平衡的电解质溶液(如林格氏乳酸盐)可以减少这些副作用的风险。口服甘露醇已经变得很流行,但根据我们的经验,只有41%的患者对制剂满意。除非在手术前立即使用口服抗菌剂(新霉素和甲硝唑),否则甘露醇会被大肠杆菌发酵成具有潜在爆炸性的气体混合物。聚乙二醇也可以引起渗透洗涤而没有爆炸的危险。我们目前倾向于用聚乙二醇和平衡电解质溶液进行鼻胃灌洗,但对于左结肠狭窄性肿瘤患者,传统的准备方法仍然需要5天以上的时间。
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Indications and techniques for bowel preparation in colorectal cancer.

A satisfactory bowel preparation is essential for adequate double contrast barium enema and colonoscopy. Efficient preparation is also important for reducing the risk of anastomotic dehiscence and sepsis in elective colorectal surgery. Traditional preparation by starvation, purgation and enemas is time consuming, unpleasant for patients, and in our experience results in a satisfactory preparation in only 23% of patients. Elemental diets are inefficient when used for only five days. Whole bowel irrigation with a nasogastric tube enables patients to be in hospital for only one day before operation and provides a satisfactory result in 61% of patients. Whole bowel irrigation is not recommended for stenosing tumours. Irrigation with saline causes sodium and water retention and the use of a balanced electrolyte solution (eg, Ringer's lactate) reduces the risk of these side effects. Oral mannitol has become popular but in our experience results in a satisfactory preparation in only 41% of patients. Mannitol is fermented by E coli to potentially explosive gas mixtures unless oral antimicrobials (neomycin and metronidazole) are used immediately before operation. Polyethylene glycol also causes osmotic catharsis without the risk of explosion. We currently favour nasogastric irrigation with polyethylene glycol and a balanced electrolyte solution, but there is still a place for traditional preparation over five days for patients with stenosing tumours of the left colon.

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