[自然和人工同种异体移植物淋巴细胞的评估(作者译)]。

J Wembacher, I Senftleber, J Gokel, C Hammer, W Brendel
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引用次数: 0

摘要

移植物中“乘客淋巴细胞”的转移引发异体排斥反应。与体外反应无差异的外周淋巴细胞相比,天然移植物和人工移植物浸润细胞是较好的刺激细胞,较差的反应细胞,但有较强的抑制细胞。这些在排斥反应中产生的t抑制细胞在移植物中富集。假设这些相对较少的淋巴细胞的功能是抑制局部免疫排斥机制。它们不能抑制外周细胞毒性细胞的增殖。
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[Assessment of lymphatic cells in natural and artificial allografts (author's transl)].

Transfer of "passenger lymphocytes" within a transplant initiates allogeneic rejection. As compared with peripheral lymphocytes, which show no different in vitro reaction, infiltrating cells from natural and artificial grafts are good stimulator, bad responder but powerful suppressor cells. These T-suppressor cells, which arose during rejection are enriched in the graft. The assumption is that the function of this relatively small number of lymphocytes is to suppress the local immunological rejection mechanisms. They cannot inhibit the proliferation of peripheral cytotoxic cells.

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