慢性弥漫性肝病乙型肝炎病毒核心抗原抗体(抗- hbc)的研究。

K Dávid, L Halmy
{"title":"慢性弥漫性肝病乙型肝炎病毒核心抗原抗体(抗- hbc)的研究。","authors":"K Dávid,&nbsp;L Halmy","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The sera of 211 patients with histological evidence of chronic diffuse liver disease were studied for antibody to hepatitis-B virus core antigen (anti-HBc), hepatitis-B virus surface antigen (HBsAg) and antibody to the latter antigen (anti-HBs) by radioimmunoassay, using Abbott-RIA kits. The frequency of anti-HBc-positivity was found to be six times as high as HBsAg-positivity and twice as high as anti-HBs-positivity. In 20 of the patients with chronic liver disease the anti-HBc-positivity was the only indicator of past infection with HB-virus. The detection-rate of HB-viral infection provided by the highly sensitive radioimmunoassays was 59 per cent in liver cirrhosis of 45 per cent in chronic hepatitis, 26 per cent in fatty degeneration of the liver. Anti-HBc having been found to be the most sensitive indicator of HB-viral infection, the importance of its assay is therefore emphasized.</p>","PeriodicalId":7041,"journal":{"name":"Acta medica Academiae Scientiarum Hungaricae","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Study of antibody to hepatitis-B virus core antigen (anti-HBc) in chronic diffuse liver disease.\",\"authors\":\"K Dávid,&nbsp;L Halmy\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The sera of 211 patients with histological evidence of chronic diffuse liver disease were studied for antibody to hepatitis-B virus core antigen (anti-HBc), hepatitis-B virus surface antigen (HBsAg) and antibody to the latter antigen (anti-HBs) by radioimmunoassay, using Abbott-RIA kits. The frequency of anti-HBc-positivity was found to be six times as high as HBsAg-positivity and twice as high as anti-HBs-positivity. In 20 of the patients with chronic liver disease the anti-HBc-positivity was the only indicator of past infection with HB-virus. The detection-rate of HB-viral infection provided by the highly sensitive radioimmunoassays was 59 per cent in liver cirrhosis of 45 per cent in chronic hepatitis, 26 per cent in fatty degeneration of the liver. Anti-HBc having been found to be the most sensitive indicator of HB-viral infection, the importance of its assay is therefore emphasized.</p>\",\"PeriodicalId\":7041,\"journal\":{\"name\":\"Acta medica Academiae Scientiarum Hungaricae\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta medica Academiae Scientiarum Hungaricae\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta medica Academiae Scientiarum Hungaricae","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

采用abbot - ria检测试剂盒,对211例有慢性弥漫性肝病组织学证据的患者血清进行了乙型肝炎病毒核心抗原(anti-HBc)、乙型肝炎病毒表面抗原(HBsAg)和后者抗体(anti-HBs)的放射免疫测定。发现抗hbc阳性的频率是hbsag阳性的6倍,是抗hbs阳性的2倍。在20例慢性肝病患者中,抗乙肝病毒阳性是过去感染乙肝病毒的唯一指标。高灵敏度放射免疫测定提供的乙肝病毒感染检出率在肝硬化中为59%,在慢性肝炎中为45%,在肝脏脂肪变性中为26%。抗hbc已被发现是乙肝病毒感染最敏感的指标,因此强调其检测的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Study of antibody to hepatitis-B virus core antigen (anti-HBc) in chronic diffuse liver disease.

The sera of 211 patients with histological evidence of chronic diffuse liver disease were studied for antibody to hepatitis-B virus core antigen (anti-HBc), hepatitis-B virus surface antigen (HBsAg) and antibody to the latter antigen (anti-HBs) by radioimmunoassay, using Abbott-RIA kits. The frequency of anti-HBc-positivity was found to be six times as high as HBsAg-positivity and twice as high as anti-HBs-positivity. In 20 of the patients with chronic liver disease the anti-HBc-positivity was the only indicator of past infection with HB-virus. The detection-rate of HB-viral infection provided by the highly sensitive radioimmunoassays was 59 per cent in liver cirrhosis of 45 per cent in chronic hepatitis, 26 per cent in fatty degeneration of the liver. Anti-HBc having been found to be the most sensitive indicator of HB-viral infection, the importance of its assay is therefore emphasized.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
The pathogenetic connection between Graves' disease and chronic lymphocytic thyroiditis. (The role and incidence of thyroid stimulating antibodies). Part of the autonomous nervous system in the development of chaotic post-extrasystolic pictures. Electrophysiological and pharmacological studies of 49 cases. Effect of metabolic control of the serum lipid and lipoprotein levels on insulin-dependent diabetes mellitus. Functional relationships of the hypothalamic-pituitary-testicular system in Graves' disease. Serum FSH and LH levels in men after administration of a long-acting LH-RH preparation.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1