荧光原位杂交法定位大鼠促红细胞生成素受体基因。

Idengaku zasshi Pub Date : 1995-08-01 DOI:10.1266/jjg.70.525
P Liang, K Kitada, M Osaka, T Serikawa, R Takahashi, Y Yamada, H Hiai, T Sugiyama
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引用次数: 0

摘要

促红细胞生成素通过结合特定的膜受体促红细胞生成素受体刺激红细胞祖细胞的增殖和分化。利用大鼠cosmid文库获得的基因组克隆,采用荧光原位杂交技术将大鼠促红细胞生成素受体基因定位到染色体8q24上。
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Chromosomal localization of the rat erythropoietin receptor gene by fluorescence in situ hybridization.

Erythropoietin stimulates proliferation and differentiation of erythroid progenitor cells by binding to a specific membrane receptor, erythropoietin receptor. By using the genomic clone derived from a rat cosmid library, the rat erythropoietin receptor gene was assigned to chromosome 8q24 by fluorescence in situ hybridization.

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