Marie Azzaria , William J. Henzel , James D. McGhee
{"title":"一种来自猪蛔虫的羧酸酯酶，与秀丽隐杆线虫肠道特异性的ges-1酯酶同源","authors":"Marie Azzaria , William J. Henzel , James D. McGhee","doi":"10.1016/0305-0491(94)90006-X","DOIUrl":null,"url":null,"abstract":"<div><p>We have identüified a carboxylesterase in <em>A. suum</em> that appears to be the homolog of the gut-specific <em>C</em>. <em>elegans</em><em>ges</em>-<em>I</em> menzyme. The <em>A. suum</em> esterase was purified and its <em>N</em>-terminal sequence found to be 50% identical to the <em>C</em>. <em>elegans</em><em>ges</em>-1 protein. We have used isoelectric focasing analysis to demonstrate that, unlike the <em>C</em>. <em>elegans</em><em>ges</em>-<em>I</em> esterase, the <em>A. suum</em> enzyme is not restricted to the gut but is expressed in a wide range of tissues.</p></div>","PeriodicalId":100294,"journal":{"name":"Comparative Biochemistry and Physiology Part B: Comparative Biochemistry","volume":"109 2","pages":"Pages 225-236"},"PeriodicalIF":0.0000,"publicationDate":"1994-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0305-0491(94)90006-X","citationCount":"0","resultStr":"{\"title\":\"A carboxylesterase from the parasitic nematode Ascaris suum homologous to the intestinal-specific ges-1 esterase of Caenorhabditis elegans\",\"authors\":\"Marie Azzaria , William J. Henzel , James D. McGhee\",\"doi\":\"10.1016/0305-0491(94)90006-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We have identüified a carboxylesterase in <em>A. suum</em> that appears to be the homolog of the gut-specific <em>C</em>. <em>elegans</em><em>ges</em>-<em>I</em> menzyme. The <em>A. suum</em> esterase was purified and its <em>N</em>-terminal sequence found to be 50% identical to the <em>C</em>. <em>elegans</em><em>ges</em>-1 protein. We have used isoelectric focasing analysis to demonstrate that, unlike the <em>C</em>. <em>elegans</em><em>ges</em>-<em>I</em> esterase, the <em>A. suum</em> enzyme is not restricted to the gut but is expressed in a wide range of tissues.</p></div>\",\"PeriodicalId\":100294,\"journal\":{\"name\":\"Comparative Biochemistry and Physiology Part B: Comparative Biochemistry\",\"volume\":\"109 2\",\"pages\":\"Pages 225-236\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0305-0491(94)90006-X\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative Biochemistry and Physiology Part B: Comparative Biochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/030504919490006X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative Biochemistry and Physiology Part B: Comparative Biochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/030504919490006X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A carboxylesterase from the parasitic nematode Ascaris suum homologous to the intestinal-specific ges-1 esterase of Caenorhabditis elegans
We have identüified a carboxylesterase in A. suum that appears to be the homolog of the gut-specific C. elegansges-I menzyme. The A. suum esterase was purified and its N-terminal sequence found to be 50% identical to the C. elegansges-1 protein. We have used isoelectric focasing analysis to demonstrate that, unlike the C. elegansges-I esterase, the A. suum enzyme is not restricted to the gut but is expressed in a wide range of tissues.
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