对不同种族间皮肤合成维生素D差异的补偿。

L Y Matsuoka, J Wortsman, T C Chen, M F Holick
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引用次数: 0

摘要

我们研究了重度黑化人群中较低皮肤维生素D合成的稳态补偿。将维生素D2 (50,000 IU)单次口服给24名年轻人,12名黑人和12名白人,年龄、性别和社会经济地位相匹配。我们还纳入了一组8名健康的老年白人成年人,作为具有非种族机制的皮肤维生素D合成减少的人群的代表。在基础条件下以及摄入维生素D后6、10和24小时进行血浆测定。黑人(12.5 +/- 2.2 ng/ml(平均+/- SEM))和老年白人(19.2 +/- 1.9 ng/ml)的基础25-羟基维生素D (25-OH-D)水平显著低于年轻白人(30.2 +/- 3.0 ng/ml (p < 0.0001));基础1,25-二羟基维生素D (1,25(OH)2 -D)水平在两组之间没有差异。口服维生素D2后各组维生素D血曲线相似。25-OH-D在黑人中增加91.7 +/- 15.9%,在年轻白人中增加18.8 +/- 5.2%,在老年白人中增加28.6 +/- 6.9;1,25(OH)2-D水平略有增加,各组之间没有差异,尽管黑色随时间变化显著(p < 0.05)。总体而言,研究群体的25-OH-D水平与峰值之间存在很强的相关性(r = -0.80;P < 0.001)。在整个测试过程中,黑人和年轻白人的完整甲状旁腺激素和血清钙水平在组内或组间没有差异。(摘要删节250字)
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Compensation for the interracial variance in the cutaneous synthesis of vitamin D.

We investigated the homeostatic compensation for the lower cutaneous synthesis of vitamin D in heavily melanized persons. Vitamin D2 (50,000 IU) was administered in a single oral dose to 24 young adults, 12 blacks and 12 whites, matched for age, gender, and socioeconomic status. We also included a group of eight healthy elderly white adults as representatives of a population with a nonracial mechanism for decreased cutaneous vitamin D synthesis. Plasma determinants were performed under basal conditions and at 6, 10, and 24 hours after vitamin D intake. Basal 25-hydroxyvitamin D (25-OH-D) levels were significantly lower in blacks (12.5 +/- 2.2 ng/ml (mean +/- SEM)) and in elderly whites (19.2 +/- 1.9 ng/ml), compared with young whites (30.2 +/- 3.0 ng/ml (p < 0.0001)); levels of basal 1,25-dihydroxyvitamin D (1,25(OH)2 -D) did not differ between groups. The vitamin D blood curve was similar between groups after the oral vitamin D2 load. Increases in 25-OH-D were 91.7 +/- 15.9% in blacks, 18.8 +/- 5.2% in young whites, and 28.6 +/- 6.9 in elderly whites; 1,25(OH)2-D levels increased slightly and did not differ between groups, although in blacks the change over time was significant (p < 0.05). As a whole, the study populations exhibited a strong relation between basal and peak 25-OH-D (r = -0.80; p < 0.001). Levels of intact parathyroid hormone and serum calcium of blacks and young whites did not differ within or between groups throughout the test.(ABSTRACT TRUNCATED AT 250 WORDS)

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