[白细胞介素-1 - β对辐射损伤有效性的实验研究]。

IF 0.2 4区医学 Q4 HEMATOLOGY Gematologiya I Transfuziologiya Pub Date : 1995-05-01

V I Legeza, N G Chigareva, N V Petkevich, T P Vasil'eva, Iu A Abdul', V N Boĭko

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引用次数: 0

摘要

对暴露于6.5 Gy, ld80 /30的小鼠进行的实验发现，在辐照后1-3小时给予人重组白细胞介素-1 β后，动物的存活率提高了40-70%。白细胞介素-1 β减少白细胞减少，增强骨髓细胞成分的恢复。使用该制剂作为辐射损伤的早期致病治疗是有希望的。

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[Experimental study of the effectiveness of interleukin-1beta in radiation injury].

The experiments on mice exposed to radiation (6.5 Gy, LD 80/30) discovered that human recombinant interleukin-1 beta after administration on postradiation hour 1-3 increased the animals' survival by 40-70%. Interleukin-1 beta reduced leukopenia and enhanced the recovery of bone marrow cell elements. The use of the preparation as an early pathogenetic treatment of irradiation damage holds promise.

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来源期刊

Gematologiya I Transfuziologiya 医学-血液学

CiteScore

0.80

自引率

66.70%

发文量

审稿时长

>12 weeks

期刊介绍： The journal publishes original theoretical and clinical studies, lectures, reviews, and practical notes concerning various problems of hematology and clinical and industrial transfusion. The journal provides information on the etiology, pathogenesis, diagnosis and treatment of blood disorders as well as on related non-hematological conditions (internal diseases, poisoning, exposure to ionizing radiation etc.).