自愿运动增加了大鼠骨骼中的成骨活动。

M Goseki, N Omi, S Oida, I Ezawa, S Sasaki
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摘要

本研究旨在探讨自主运动对大鼠骨成骨活性的影响。让Sprague-Dawley雄性和雌性大鼠在跑步机上自由运动,或作为对照组不运动53天。将实验组大鼠和对照组大鼠的脱钙肱骨骨干腹腔内植入宿主大鼠,33天后取出。通过软x线摄影和碱性磷酸酶活性和矿物质含量的测定,证实跑步组植入的骨基质与对照组相比骨形成明显增加。运动增加了雄性和雌性动物骨骼和血清中碱性磷酸酶活性。结果表明,骨中的骨诱导活性可能是由于自发运动后骨形态发生蛋白水平的增加。
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Voluntary exercise increases osteogenetic activity in rat bones.

The purpose of this study was to investigate the effect of voluntary exercise on osteoinductive activity in rat bone. Sprague-Dawley male and female rats were allowed to exercise freely by running on a treadmill or kept as controls without exercise for 53 days. Decalcified humeral diaphyses from experimental and control rats were implanted intraperitoneally into host rats and harvested after 33 days. A significant increase in bone formation was confirmed in the implanted bone matrices from the running group in comparison with those from control animals by soft X-ray photography and determination of alkaline phosphatase activity and mineral content. Alkaline phosphatase activity in bone and serum was increased by exercise in both male and female animals. The results suggest that osteoinductive activity in the bone was probably due to increased levels of bone morphogenetic protein following voluntary exercise.

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